BIO 2018 Advanced Partnering Webinar: Partnering Power Tools

Latent cardiovascular toxicity issues continue to plague late-stage drug discovery efforts, as well as commercially launched pharmaceutical success. Many current in vitro models lack, or incompletely recapitulate, important aspects of human cardiac biology, thus allowing certain toxicities to escape detection until the non-human primate and clinical trial stages of drug development. Induced pluripotent stem cell (iPSC) technology brings relevant human biology to the laboratory and with it, great promise for early predictive detection of cardiotoxicity.

Upstream process development labs have historically depended on a core lab to get a picture of changes in critical media nutrients inside a bioreactor. While this became the norm, with results being delivered in weeks rather than days, the data was at least useful enough to inform future endeavors. However, recent breakthroughs in technology have changed that, as it is now possible to obtain a rapid at-line analysis of your cell media to make decisions on the fly. This webinar will introduce a powerful new platform and walk-through ways to boost your bioprocessing workflow by simply checking in more frequently. The content directly relates to anyone who is doing media quality control, media selection, or in-process media optimization and wants to accelerate their work.

This technical video provides an overview of the methodologies, tools, and reagents used to generate multicellular tumor spheroids. Specifically, this video discusses the benefits of Cultrex® extracellular matrices for spheroid formation and analysis. Technical tips are provided for using colorimetric and fluorometric assays to evaluate cell proliferation and invasion of spheroids. This protocol video was originally recorded by Dr. Gabriel Benton at Trevigen, Inc. The Trevigen portfolio, including tools for creating 3-D and spheroid cultures, is now a part of R&D Systems, a Bio-Techne brand.

Proteolysis-targeting chimeras (PROTACs) are a class of bifunctional molecules which are enabling the development of drugs against targets once considered inaccessible.