Accurate Prediction of On- and Off-Target Cardiotoxicity with Human iPSC-Derived Cardiomyocytes

From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in research due to their role as intercellular messengers in health and disease. While their translational applications appear unlimited, the study of exosomes is challenged by their small size and heterogenous nature. In this webinar you will learn more about the common methods for exosome research and the proficient tools that Miltenyi Biotec offers to isolate and analyze exosomes. Join to connect with us and hear more.

This technical video provides an overview of the methodologies, tools, and reagents used to generate multicellular tumor spheroids. Specifically, this video discusses the benefits of Cultrex® extracellular matrices for spheroid formation and analysis. Technical tips are provided for using colorimetric and fluorometric assays to evaluate cell proliferation and invasion of spheroids. This protocol video was originally recorded by Dr. Gabriel Benton at Trevigen, Inc. The Trevigen portfolio, including tools for creating 3-D and spheroid cultures, is now a part of R&D Systems, a Bio-Techne brand.

Together with product efficacy, product safety is an essential characteristic of any medicinal product including cell and gene therapy (C>) biologics. Adventitious agents (viruses, bacteria, mycoplasma, prions, etc) pose constant risk to these biologics, and, as such they may impact directly product and patient safety.

Single-Pass Tangential Flow Filtration (SPTFF) is a technology that requires only one pass through the filter assembly to achieve the desired concentration with no recirculation of product.