Challenges in Translating iPSC Technology

Proteins are the molecular workhorses of life. In order for them to perform their physiological function, they need to be folded into unique 3D structures.

The advent of single cell approaches for studying chromatin accessibility, including single-cell ATAC-seq and single-cell RNA-seq, has enabled characterization of epigenomes at single cell resolution. These studies contribute to a systems-level understanding of epigenomic variation at the single-cell level, allowing detection and assessment of an important driver of cell-to-cell heterogeneity.

In this Close to the Edge new live series, we’ll be interviewing chief executives and scientific and business leaders from the biotech spectrum. In this inaugural episode on May 12 GEN Edge welcomes Christian Henry, the CEO of PacBio, for an exclusive interview.

Cell culture is the unsung workhorse of biopharmaceutical drug development, yet it is so often the essential backbone of discovery projects. The growth of cells in laboratory settings constitutes a wide assortment of factors for their appropriate growth, with environmental conditions raking at the top of the list of importance. Reliable incubator technology is critical to yielding the high-quality results investigators are constantly seeking. Moreover, with respect to GMP, incubator technology must include algorithmic control systems and safeguards designed to protect the cell culture or cell-expressed product, particularly when associated with direct human applications such as cell-derived biologics and whole-cell therapies.