Accelerated and AI-Based Genomic Workflows On-Prem and in the Cloud

In celebration of GEN’s 40th year in publishing, GEN Live will feature a panel of biotech reporters and scientists who have been covering the bioindustry since the early 1980s. Moreover, each wrote some of their initial biotech articles for GEN just as the industry, and GEN, was taking off.

MicroRNA(miRNA) are short non-coding single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. They are known to play a critical role in multiple biological processes including proliferation, differentiation, apoptosis, and hematopoiesis. Dysregulation of miRNA expression, therefore, is associated with a number of pathological conditions such as inflammation, cardiovascular diseases, neurological disorders and several types of cancers. miRNAs are also found to be extremely stable in body fluids such as serum, plasma, urine, breast milk, and saliva. Extracellular miRNAs are either packed into exosomes or loaded into high-density lipoproteins or bound by AGO2 proteins outside on vesicles. These modes of action protect miRNAs from degradation and improve their stability. Because of their stability in body fluids, miRNAs are gaining importance as biomarkers in liquid biopsies.

In this webinar, Dr. Penney Gilbert from the University of Toronto explains how her group has uncovered regulators of muscle hypertrophy by inducing exercise-like rounds of contractions in their 3D skeletal muscle models.

There are approximately 7,000 distinct rare diseases affecting 350 million people worldwide, approximately 80 percent of which are caused by faulty genes.