Strategies to normalize miRNA expression in serum and plasma

MicroRNA(miRNA) are short non-coding single-stranded RNA molecules that regulate gene expression at the post-transcriptional level.  They are known to play a critical role in multiple biological processes including proliferation, differentiation, apoptosis, and hematopoiesis. Dysregulation of miRNA expression, therefore, is associated with a number of pathological conditions such as inflammation, cardiovascular diseases, neurological disorders and several types of cancers. miRNAs are also found to be extremely stable in body fluids such as serum, plasma, urine, breast milk, and saliva. Extracellular miRNAs are either packed into exosomes or loaded into high-density lipoproteins or bound by AGO2 proteins outside on vesicles. These modes of action protect miRNAs from degradation and improve their stability. Because of their stability in body fluids, miRNAs are gaining importance as biomarkers in liquid biopsies.
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OTHER ON-DEMAND WEBINARS

Talking to Patients about Genetic Testing and the Potential Psychosocial Implications of that Discussion

Ambry Genetics

Dr. Hurley will provide an overview of psychosocial challenges faced by patients deciding to undergo genetic testing. Her presentation will combine research findings from psychosocial research and case illustrations from twenty years of providing psychotherapy to genetic counseling patients. She will provide tips on communication strategies as well as common pitfalls to avoid, and discuss advantages of creating an “information plan” based on patients’ needs, preferences, and ability to absorb emotionally challenging information. Clinical examples will be drawn from Dr. Hurley’s specialty in hereditary cancer risk, with the discussion of how psychosocial issues in genetic testing are relevant across a broad range of conditions, from the prenatal setting to other pediatric- and adult-onset hereditary syndromes.
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Unravelling cancer immunity and immunotherapy response using multi-omics

Multi-omics approaches integrate multiple omics data generated from cancer patients to better understand the molecular and clinical features of cancer. Multi-omics technologies, including genomics, proteomics, and metabolomics, have also been included in clinical trials to understand the response to immunotherapy and the mechanisms of drug resistance.
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High Throughput, Low Volume Subvisible Particle Analysis

Halo Labs

Subvisible particle analysis is a key predictor of protein drug stability and a key formulation, quality metric. However, current methods use large volumes of precious protein solutions and are labor- and time-intensive, making this data inaccessible during late-stage candidate screening or early in formulation. Moreover, regulatory agencies are tightly enforcing subvisible particle content in biopharma formulations at unprecedented levels, making early detection of subvisible particles, like protein aggregates, a key analytical priority.
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How to interpret clinical trial results like a pro

statnews

Clinical trial data can be remarkably (and unnecessarily) difficult to read. Companies spin, short-sellers hawk, and everyone else is left swimming through the muck. But there is an art to reading scientific results — and you can learn it.
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