Rapid and Precise Biosimilar Candidate Profiling by nanoDSF

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The development of biosimilars requires extensive physicochemical characterization of biosimilar candidate molecules which should match the quality profile of the reference molecule (originator). Here we use a novel method of thermal unfolding profiling to rapidly screen a variety of Fc-fusion protein biosimilar candidates. The best-in-class precision of the NanoTemper Technologies Prometheus NT.48 nanoDSF instrument allowed for the ranking of biosimilar candidates according to the comparability of their unfolding profiles to the reference molecule. The results were in excellent agreement with conventional screening methods, while dramatically reducing sample consumption and measurement times. Thus, nanoDSF (miniaturized differential scanning fluorimetry) is a new and powerful tool for rapid screening approaches in biosimilar development. It enables narrowing down the number of promising candidates in hours instead of days or weeks.

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Igenomix

IGENOMIX is a company that provides advanced services in reproductive genetics. Our broad experience and qualifications make us one of the global leaders in this field. Our constant efforts in R&D, led by Prof. Dr. Carlos Simón (2011 Jaime I award-winner for Clinical Research), enable us to create and develop specific tools to support professionals in the reproductive medicine field.

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