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Autophagy in Neurodegenerative Diseases

February 6, 2019

Neurodegenerative diseases differ substantially in their effects on various neuronal populations and brain regions, however, the accumulation of intracellular, pathogenic protein aggregates and the progressive loss of cellular function due to neuronal synaptic impairment seem to be common to all NDDs. Although the molecular nature of the specific pathogenic proteins differs among NDDs, each condition seems to be associated with the chronic accumulation of vesicular organelles within affected neurons.

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