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Advantages of long reads for genome assembly

September 15, 2017

Over the last decade, improvements in next generation DNA sequencing technology have transformed the field of genomics, making it an essential tool in modern genetic and clinical research laboratories. The facility to sequence whole genomes or specific genomic regions of interest is delivering new insights into a variety of applications such as human health and disease, metagenomics, antimicrobial resistance, evolutionary biology, and crop breeding. One of the key steps of WGS is the accurate assembly of the vast amount of data generated into a contiguous stretch of DNA sequence. This review provides a background to the DNA assembly process and the associated advantages of long or ultra-long DNA read, as provided by nanopore sequencing technology

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