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biospace | May 17, 2019
AbbVie announced that it has halted its Phase III INTELLANCE-1 clinical trial of depatuxizumab mafodotin (Depatux-M) in patients with newly diagnosed glioblastoma (GBM) whose tumors have epidermal growth factor receptor (EGFR) amplification. An Independent Data Monitoring Committee (IDMC) recommended the trial be stopped because of lack of survival benefit for patients receiving the drug compared to placebo. The trial compared the efficacy and safety of Depatux-M compared to placebo when given w...
fiercebiotech | May 14, 2019
A phase 3 trial of Myovant Sciences' uterine fibroid drug relugolix has hit its primary endpoint, moving the Roivant unit a step closer to a planned filing for approval. The drug comfortably beat placebo against a slew of efficacy endpoints and posted comparable safety and tolerability to the control. Myovant, part of Roivant’s stable of biotechs, picked up the global rights to relugolix from Takeda Pharmaceutical in 2016 and moved it into a pair of phase 3 trials the following year. R...
Labiotech.eu | January 28, 2020
A Swiss research group has developed tiny plastic particles that could carry gene therapies to the center of the cell with less risk of getting attacked by the immune system than conventional gene therapies. The majority of gene therapies in use today are delivered to the DNA of target cells using viral vectors. While efficient at their job, viral vectors can risk triggering the immune system to destroy them. This can lead to the therapy becoming ineffective....
FierceBiotech | January 27, 2020
Johnson & Johnson is joining the growing ranks of biopharmas, including the likes of Moderna and Gilead Sciences, in trying to create a speedy vaccine for the coronavirus out of China. Over the weekend, we learned of a wider range and more deaths as the new virus, which appears to have come out of Wuhan, China, is doing what these diseases do best: spread. The causes of death have so far been reported as pneumonia, with other reports suggesting most of these have come from those with underly...
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