Xylyx Bio Releases Normal and Fibrotic NativeCoat™ ECM Substrates Increase Predictiveness of High Throughput Compound Screening

New York-based Xylyx Bio, a leader in advanced disease models, today announced the release of normal and fibrotic NativeCoat™ human lung- and liver-specific ECM substrates for antifibrotic drug discovery to increase predictiveness of high throughput screening and improve evaluation of efficacy of biopharmaceutical drug candidates for hard to treat fibrotic diseases such as IPF and NASH. Despite billions of dollars spent each year, 9 out of 10 drugs fail to make it to market, in part due to the lack of translatability of preclinical data to humans. Existing models do not replicate the complexity of human disease, impeding the translation of research to patients and contributing to numerous and expensive drug failures. To address this need, NativeCoat™ substrates harness the power of human disease-specific extracellular matrix (ECM) to combine the advantages of scalability and throughput with the ability to incorporate higher-level biology and generate translatable data.