Mission Bio Announced the Launch of First Single-Cell Genomics Solid Tumor Solution on the Tapestri Platform

Mission Bio | March 30, 2022

Mission Bio, Inc., a pioneer in high-throughput single-cell DNA and multi-omics research, announced the commercial availability of the Tapestri Solution for Solid Tumor Research. On the Tapestri Platform, this new end-to-end single-cell DNA sequencing process comprises a nuclei isolation prep technique, pre-designed research panels for breast cancer and glioblastoma multiforme, and an enhanced single-cell copy number variation (CNV) bioinformatic analysis tool. Mission Bio currently covers solid tumors in addition to hematologic malignancies, where Tapestri is widely used to study tumor heterogeneity and gain new insights into the clonal variety and architecture driving disease progression, biomarkers, and therapeutic management.

Recent high-profile research studies utilizing custom Tapestri assays for breast cancer, non-small cell lung cancer, colorectal cancer, and melanoma have demonstrated the utility of high-resolution tools for assessing solid tumor heterogeneity and clonal evolution, which contribute to disease onset, progression, and relapse. However, bulk next-generation sequencing technologies cannot offer the cell-by-cell mutational data required to detect disease-causing biological drivers — they are confined to population-level average metrics and lack information on clonal diversity.

Tapestri quantifies DNA mutations at the individual cell level in thousands of cells simultaneously, simultaneously detecting SNVs, indels, and CNVs, conclusively identifying variant zygosity and mutational co-occurrence recognizing unusual cell populations. As a result, researchers studying solid tumors may now make use of a comprehensive workflow designed for the Tapestri Platform, which includes the following:

  • Sample preparation assistance with an enhanced nuclei isolation process for both fresh and frozen samples
  • New study panels for breast cancer and glioblastoma were meticulously selected to contain hotspot genes, copy number variants, and chromosomal arm aneuploidies linked with each illness. Additionally, users may create custom panels that target specific human or mouse genome regions.
  • Enhanced capacity for CNV bioinformatics analysis with the development of a new visualization tool (in collaboration with Mission Bio's Field Application Scientist team).

This integrated workflow approach has the potential to significantly advance our knowledge of disease progression and enable the development of more specific medicines.

The commercial introduction of Mission Bio's Tapestri Solution for Solid Tumor Research demonstrates the company's ongoing commitment to allowing more precise cancer research using single-cell DNA sequencing. In addition, mission Bio has announced the establishment of its first Center of Excellence for solid tumor single-cell DNA profiling at Memorial Sloan Kettering Cancer Center (MSKCC).

The impressive results already seen from our early work with solid tumor researchers helped guide the development of these new workflows and underscored our commitment to providing unique and indispensable tools for solid tumor researchers. Just as Tapestri has been an invaluable tool for hematologic malignancy researchers, we're confident that our research panel pair, new prep protocol, and improved bioinformatics analysis capabilities will demonstrate the platform's value in solid tumors."

CEO of Mission Bio, Yan Zhang, Ph.D., said.


What is a genome, and how are traits passed from generation to generation? Learn how pea plants helped launch the study of genetics and how the field of genetics research has evolved over time.

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Kintor Pharma Provides Update on One of its Three Multi-Regional Phase 3 Trials of Proxalutamide for COVID-19

Kintor Pharma | December 29, 2021

Kintor Pharmaceutical Limited, a clinical-stage biotechnology company developing innovative small molecule and biological therapeutics, provided an update on its multi-regional study of proxalutamide for the treatment of COVID-19 infection. Statistical criteria were not met at an interim analysis of the phase III outpatient study, designed for testing efficacy and safety of proxalutamide for treating COVID-19 in non-hospitalized COVID-19 patients. At the interim analysis, 348 patients with mild-to-moderate COVID-19 symptoms were enrolled. Kintor Pharma will seek for Health Authorities including the U.S. Food & Drug Administration's consent to amend the protocol and continue to enroll higher risk COVID-19 patients only with multiple comorbidities and/or patients with no COVID-19 vaccination history. Based on the interim analysis, there were no safety concerns and no drug-related serious adverse events reported during the study. As of December 23, 2021, Kintor Pharma had completed the enrollment of this pivotal study according to the original protocol. More than 95 percent of the enrolled patients were from the U.S. For the interim analysis, all patients were from the U.S., where the hospitalization rate is very low. "The COVID-19 pandemic continues to evolve with the Omicron variant highlighting the need for therapeutics. It is important to investigate new modalities to treat those infected with the virus. We believe proxalutamide could become an important tool in the fight against COVID-19 infection and will continue to investigate its use. We will provide updates on the final data analysis from this outpatient clinical trial in due course." Dr. Youzhi Tong, founder, Chairman, and Chief Executive Officer of Kintor Pharma The outpatient study is a randomized, double-blind, placebo-controlled Phase III study designed to evaluate the efficacy and safety of proxalutamide in outpatients with mild to moderate COVID-19 illness. For the interim analysis, the trial enrolled 348 male and female patients with one or more mild COVID-19-related symptoms within five days of symptoms onset. Participants were randomized to receive proxalutamide or placebo orally twice daily for 14 days. The enrolment covers the whole population including patients with a vaccination history, as well as without any risk factors. Both the treatment arm and placebo arm were given standard of care. The primary endpoint was the percentage of all-cause death and hospitalization for a period exceeding 24 hours by day 28. About Kintor's Multi-Regional Clinical Trials for Proxalutamide Kintor Pharma is conducting two registered Phase III multi-regional clinical trials of proxalutamide for the treatment of COVID-19 outpatients, and one Phase III MRCT for COVID-19 inpatients in countries and regions that include the United States, South America, Asia and the European Union. The second outpatient study plans to enroll 724 patients, with the primary endpoint of percentage of subjects requiring oxygen by day 28. The inpatient study is a randomized, double-blind, placebo-controlled Phase III study. Male and non-pregnant female hospitalized adults are included. The primary endpoint is time to sustained recovery, and the key secondary endpoint is percentage of all-cause mortality. Kintor Pharma was granted an emergency use authorization for proxalutamide for the treatment of COVID-19 infection in hospitalized patients in Paraguay. About Proxalutamide Proxalutamide is a nonsteroidal antiandrogen — specifically, a selective high-affinity silent antagonist of the androgen receptor — that is under development for the potential treatment of COVID-19, prostate cancer, and breast cancer. Targeting AR-ACE2/TMPRSS2 signal axis by proxalutamide could significantly inhibit the entry of the virus into host cells by transcriptionally down-regulating the expression of TMRPSS2 and ACE2. Proxalutamide promotes the clearance of pathogens and decreases inflammation by activating the Nrf2 pathway, which inhibits the overproduction of IL-6, proinflammatory cytokines, and chemokines. This mechanism of action reduces the intensity of the cytokine response, which may be of clinical benefit to patients with COVID-19 infection. About Kintor Pharmaceutical Limited Kintor Pharmaceutical Limited is developing and commercializing a robust pipeline of innovative small molecule and biological therapeutics for androgen-receptor-related disease areas with unmet medical needs, including COVID-19, prostate, breast and liver cancer, alopecia and acne.

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Enzychem Lifesciences Announces Formation of Corporate Advisory Committee

Enzychem Lifesciences | March 03, 2022

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Agilent and A*STAR’s SIFBI Sign Research Collaboration Agreement to Advance Singapore Agri-Food Industry

Agilent Technologies Inc. | January 27, 2022

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Cardea Bio completes planned launch of CRISPR QC

Cardea Bio | April 06, 2022

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What is a genome, and how are traits passed from generation to generation? Learn how pea plants helped launch the study of genetics and how the field of genetics research has evolved over time.