Editing Technology to Identify and Advance Genetic Dysfunction Therapies

BlueAllele | July 27, 2020

Editing Technology to Identify and Advance Genetic Dysfunction Therapies
BlueAllele, a biotechnology company focused on enhancing the quality and precision of gene editing systems for patients with genetic diseases, announced the launch of PALIDON™, an innovative and proprietary repair template technology. Many rare genetic diseases are caused by mutations within a single gene. However, the location of the mutation often varies for different individuals with the same disease. Conventional gene editing approaches are primarily limited to correcting small regions or even single locations. Additionally, repair templates have failed to achieve sufficient integration efficiency in vivo needed to sustain therapeutic thresholds and durable efficacy. BlueAllele's PALIDON repair templates were designed to specifically overcome both of these challenges. PALIDON's "bi-directional" templates use a reverse-complementary structure that is designed to leverage the high rate of non-homologous end joining (NHEJ) repair observed in cells while preserving the ability to achieve precise correction of damaged mRNA and protein. PALIDON templates are designed to be compatible with existing gene editing tools (e.g., CRISPR, zinc-finger nucleases) and delivery systems, making them particularly suitable for targeting a variety of genetic diseases.

Spotlight

Bioinformatics is the application of information technology to the study of living things, usually at the molecular level. Bioinformatics involves the use of computers to collect, organize and use biological information to answer questions in fields like evolutionary biology.


Other News

Selected Notes From Wall Street Analysts On Applied DNA Sciences, Inc. (APDN)

US Post News | April 16, 2020

On Wednesday, shares of Applied DNA Sciences, Inc. (NASDAQ:APDN) marked $5.76 per share versus a previous $4.55 closing price. With having a 26.59% gain, an insight into the fundamental values of Applied DNA Sciences, Inc., investors would also find a great ally in the technical patterns of the stock movements showed in stock charts. APDN showed a rise of 37.47% within its YTD performance, with highs and lows between $2.52 – $33.60 during the period of 52 weeks, compared to the simple moving average of -26.60% in the period of the last 200 days. Maxim Group equity researchers changed the status of Applied DNA Sciences, Inc. (NASDAQ: APDN) shares to a “Buy” rating in the report published on November 14th, 2016. Other analysts, including Maxim Group, also published their reports on APDN shares. Maxim Group repeated the rating from the previous report, marking APDN under “Buy” rating, in the report published on May 13th, 2016. Additionally, APDN shares got another “Buy” rating from Maxim Group, setting a target price of $13 on the company’s shares, according to the report published in October 8th, 2015.

Read More

AVM Biotechnology has FDA Approval for Clinical Trials for Promising New Cancer Treatment

PR Newswire | April 14, 2020

Seattle's AVM Biotechnology announces clinical trial approval for AVM0703, an exciting new drug to treat terminal no-option Non-Hodgkins Lymphoma, Acute Lymphocytic Leukemia and Chronic Lymphocytic Leukemia. We are seeking patients to begin Phase I/II trials. Compassionate use will be considered under US FDA guidelines. More information can be found here: clinicaltrials.gov. AVM0703 works by supercharging and mobilizing the immune cells within all of us. When a patient is treated with AVM0703 supercharged immune cells (natural killer T-cells, gamma delta T cells and dendritic cells) invade and destroy tumors more powerfully than untreated immune cells. Because of its mechanism of action, AVM0703 is also a potential treatment for viruses like COVID-19. Within 2-7 days after treatment a patient will know whether they have responded. If there is no response that leaves other treatment options open.

Read More

Coronavirus Testing Kits Market is Booming Worldwide, BioMednomics, GenMark Diagnostics, Getein Biotech

openPR.com | April 13, 2020

Advance Market Analytics released the research report of Global Coronavirus Testing Kits Market, offers a detailed overview of the factors influencing the global business scope. Global Coronavirus Testing Kits Market research report shows the latest market insights with upcoming trends and breakdown of the products and services. The report provides key statistics on the market status, size, share, growth factors of the Global Coronavirus Testing Kits. This Report covers the emerging player's data, including: competitive situation, sales, revenue and global market share of top manufacturers are MyLab (India), Altona Diagnostics (Germany), BioMednomics (United States), Getein Biotech (China), Sensing Self Ltd (Singapore), AmonMed Biotechnology Co (China), Biomaxima (Poland), CTK Biotech (United States), Vivacheck Lab (China), Hangzhou Biotest Biotech (China), Wondfo (China), GenMark Diagnostics, Inc. (United States), XCR Diagnostics (United States), SensDx S.A.

Read More

Ancient Submerged Cypress Forest Could Hold Potential For New Medicines, Biotechnology

IFLScience | April 09, 2020

A 60,000-year-old forest submerged in the Gulf of Mexico may hold potential for the development of new medicines and biotechnology in the future – and scientists are only just beginning to understand what other secrets it may hold. Along the banks of a river in Alabama was once a flourishing bald cypress forest. As the trees grew and died, they eventually fell and become buried in peat and sediment. Over time, sea levels rose and covered the ancient forest far beneath the surface of the ocean in what would eventually become a unique and isolated habitat for marine organisms. Intensifying storm systems have recently disturbed the seafloor to expose these large logs, which have become a bit of a reef-like marine ecosystem home to wood-eating “shipworms,” which are technically clams (Teredinid bivalve). These shipworms are also known as the “termites of the sea” – a nickname they’ve received thanks to their ability to convert wood into animal tissue that forms the foundation of the deep-sea food chain.

Read More

Spotlight

Bioinformatics is the application of information technology to the study of living things, usually at the molecular level. Bioinformatics involves the use of computers to collect, organize and use biological information to answer questions in fields like evolutionary biology.

Resources