Undergraduate Neuroscience Pedagogy: Perspectives From Different Institutions

Single cell analysis, starting with the earliest low parameter fluorescent experiments, helped define the major cell subsets of human cellular systems as we understand them today. Now, a novel combination of single cell analysis and metal isotopes based mass spectrometry (MIBI) offers a routine examination of 30+ parameters at the nanometer scale, without the interference of spectral overlap characteristic of fluorescent reporters. With this platform, we have reached new levels of organizational understanding in human pathobiology – especially when combined with novel single-cell visualization and analysis methods.

Webinar presenters Dana Chase, MD, FACOG,Assistant Professor, Division of Gynecologic Oncology University of Arizona College of Medicine, Phoenix, AZ, Creighton University School of Medicine at St. Joseph’s Hospital, Phoenix, AZ, Gynecologic Oncologist, Arizona Oncology, and John Longshore, PhD, FACMG, Director, Molecular Pathology, Carolinas Pathology Group, Carolinas HealthCare System, Charlotte, North Carolina, discuss the link between molecular profiles and disease pathogenesis in ovarian cancer, the clinical significance of PARP inhibition in BRCA1 and/or 2–mutated ovarian cancer, the testing process for BRCA mutations, and the evolving paradigms in tumor and germline BRCA testing in ovarian cancer.

Although not directly reporting neuronal activity, blood flow-based neuroimaging techniques like BOLD fMRI are the most widely used to image brain activity.

Today, cost pressure, market uncertainty, and market growth challenge the existing manufacturing technologies. With the rise of these more complex molecules often comes the challenge of manufacturing them cost-effective. One of the approaches that contract manufacturing organizations and drug development companies take to increase their manufacturing output is utilizing perfusion and process-intensive technologies. One of the challenges in such efforts is the adaptation of cells to very different culture conditions, which requires a sufficiently flexible cell and a good understanding of process requirements to maximize performance.