The retina is a multilayered, highly heterogeneous neuronal tissue with intricate cellular interactions. Single-cell multiomics allows us to take steps toward understanding the biology of this complex tissue through the ability to identify and characterize all cell subtypes. Thus, a single cell transcriptomic and epigenomic atlas of the retina can be a valuable resource in opening new opportunities for future mechanistic studies.
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siremlab
For common groundwater contaminants such as chlorinated ethenes, demonstrating biodegradation activity based on detection of daughter products is straightforward, since the products are readily discernible from background sources. However, this is not the case for all contaminants. With chlorinated methane’s (i.e., carbon tetrachloride, chloroform, and dichloromethane), for example, anaerobic reductive dichlorination is not the only degradation pathway.
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Liquid biopsy, utilizing blood as a less invasive alternative for tissue samples, is becoming more and more prominent in precision medicine. The possibility to analyze blood samples across the species matrix makes mass spectrometry-based proteomics a powerful tool for early-stage, translational, and clinical research.
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Labroots
Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioritize novel targets for drug development and improve the design of genetically reprogrammed cell-based therapies.
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