Optimizing Biotherapeutic Cell Lines for Continuous Manufacturing

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Today, cost pressure, market uncertainty, and market growth challenge the existing manufacturing technologies. With the rise of these more complex molecules often comes the challenge of manufacturing them cost-effective. One of the approaches that contract manufacturing organizations and drug development companies take to increase their manufacturing output is utilizing perfusion and process-intensive technologies. One of the challenges in such efforts is the adaptation of cells to very different culture conditions, which requires a sufficiently flexible cell and a good understanding of process requirements to maximize performance.
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OTHER ON-DEMAND WEBINARS

Innovative Technology for Scalable, Plasmid-Free Production

Adeno-associated viral vectors are essential tools for delivering gene therapy to patients and are usually manufactured using plasmid-based approaches. However, there are challenges with working with plasmids on a large scale, including consistency and scalability.
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Cell and Gene Therapies: From Concept to Commercialization

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The voyage of a cell or gene therapy from initial hypothesis to commercial delivery is complex and challenging. It requires a broad spectrum of scientific expertise, innovative technologies, and optimized processes to ensure these advanced therapeutics make it to market. In this GEN webinar, our panelists—two industry leaders—will discuss what it takes to develop a cell or gene therapy from concept to commercialization, alongside a conversation about innovations that are likely to shape the future of advanced therapy discovery and biomanufacturing.
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How Computational Life Sciences Enables Metagenomics Studies

Big datasets are a challenge to analyze. While all the “omics” crank out data by the terabyte, it hardly gets any bigger and messier than metagenomics data.
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Implementation of Biopreservation Best Practices to address a critical component of cell and gene therapy manufacturing

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There is more to Biopreservation than storage on ice or freezing at a rate of -1°C/min. To comprehend the rationale behind Biopreservation Best Practices, a basic understanding of cellular response to cold and freezing is essential. This presentation will identify the critical process parameters (CPPs) of Cold Chain, such as freezing and thawing rates, storage and post-thaw stability, and container type, among others, and will discuss the impact of these CPPs on critical quality attributes (CQAs) such as viability, yield, proliferation rate, and return to function.
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