mRNA Synthesis Considerations for Vaccine and Therapeutic Development

Immune systems are found in most living organisms. They reflect the common challenges of existing in a potentially hostile external environment and often exhibit a complex, ever-changing interplay between specialized cell types, potent effector molecules, and exogenously acquired molecules and organisms. In our own immune systems, changes in the delicate homeostatic balance can lead to major problems, such as allergic responses or autoimmune diseases. Understanding how our immune system functions are difficult because of the plethora of different cell types and biomolecules involved, and because of its extremely dynamic nature.

As it is with so many things in life, how we begin often sets the tone for the entire journey. Bioproduction endeavors are no different. Using robust reagents and developing reproducible procedures at the early stages of your bioprocess is critical to producing a safe and efficacious final product. Upstream process scientists are constantly trying to improve parameters such as growth conditions, media analysis, and optimizing cell lines to ease the burden on downstream purification steps. Determining the best way to begin your bioproduction journey takes a lot of experience and can often seem daunting. However, in this presentation, our panelists will tell us what’s necessary for those initial successful steps.

It is increasingly appreciated that crosstalk at the nexus of the nervous and immune systems mediates a delicate balance between dysregulation and homeostasis across many important biological processes. In this Cell Press webinar, three speakers will explore emerging developments in our understanding of mediators and mechanisms of neuro-immune interplay.

Privately held Aprecia Pharmaceuticals, LLC (Aprecia) and CMIC CMO Co., LTD (CMIC CMO) today announced that both companies will collaborate to develop business opportunities in Japan for Aprecias ZipDoseTechnology. CMIC CMOs services will include identifying prospects in Japan, generating awareness and facilitating discussions of technology licensing agreements, research collaborations and distribution partnerships. Through this engagement Aprecia seeks to expand its 3DP products globally, and this agreement highlights the importance of Japan in its long term strategy.