MANAGING BIOLOGICS PROCESS ANALYTICAL TECHNOLOGY IN PFIZER

T cell receptors (TCRs) allow the adaptive immune system to recognize and respond to a vast array of threats, ranging from viruses to malignant cells. Single-cell sequencing has made it possible to explore an individual’s TCR repertoire and quantify changes due to an immune response. To fully unlock the great potential of these measurements we need to know which antigens each TCR binds.

As the prevalence of diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that will aid in the diagnosis and management of patients. This is a complex process that poses challenges for patients, physicians, hospitals and laboratories. What is changing in today’s world is that many hospitals are being asked to take steps toward improving proactive and preventive care, improving patient outcomes while also saving on healthcare costs associated with diabetes and diabetes complications. Laboratories are invaluable partners in addressing this challenge.

Screening cancer patients for microsatellite instability (MSI) can provide pathologists, oncologists, and patients with information that characterizes tumors to help guide care and make more informed decisions.

There are over 7000 rare diseases worldwide, and unfortunately, less than five percent have an FDA approved therapy. The lack of valid animal models remains one of the biggest hurdles for preclinical drug discovery for rare diseases. However, recent technology advances can enable the development of innovative rodent models to speed up the drug discovery process.