Initial Evaluation of the ClearLLab 10C System in the Immunophenotyping of Leukemia and Lymphoma

The last few years have seen the scale of single cell RNA-seq experiments increase exponentially, greatly enhancing our understanding of cell biology in development and disease. It is now feasible for researchers to characterize thousands of single cells in one experiment. However, important hallmarks of immune cell states are often not detected in scRNA-seq experiments. While lower throughput methods previously allowed researchers to link phenotypes or protein expression to transcriptomic profiles, the increase in scale of modern droplet-based methods resulted in a loss of such addressability.

As the prevalence of diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that will aid in the diagnosis and management of patients. This is a complex process that poses challenges for patients, physicians, hospitals and laboratories. What is changing in today’s world is that many hospitals are being asked to take steps toward improving proactive and preventive care, improving patient outcomes while also saving on healthcare costs associated with diabetes and diabetes complications. Laboratories are invaluable partners in addressing this challenge.

The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to assist in thyroid disease management. During this session, Dr. Aw will provide a brief introduction to thyroid disease, as well as the clinical guidelines related to thyroid function tests (TFTs). Dr. Aw will also go on to explain the advantages of using TFTs as an effective tool with which to monitor thyroid health. Further, Dr. Aw will shed light on the clinical relevance and utilization of the thyrotropin receptor antibody (TRAb) test, while considering published data and findings to outline its benefits. Join us to learn more about the important role that the laboratory plays in assessing thyroid health and disease management.

MicroRNA(miRNA) are short non-coding single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. They are known to play a critical role in multiple biological processes including proliferation, differentiation, apoptosis, and hematopoiesis. Dysregulation of miRNA expression, therefore, is associated with a number of pathological conditions such as inflammation, cardiovascular diseases, neurological disorders and several types of cancers. miRNAs are also found to be extremely stable in body fluids such as serum, plasma, urine, breast milk, and saliva. Extracellular miRNAs are either packed into exosomes or loaded into high-density lipoproteins or bound by AGO2 proteins outside on vesicles. These modes of action protect miRNAs from degradation and improve their stability. Because of their stability in body fluids, miRNAs are gaining importance as biomarkers in liquid biopsies.