Implementation of Biopreservation Best Practices to address a critical component of cell and gene therapy manufacturing

Parabricks has accelerated the secondary analysis of sequencing data to analyze a 30X whole genome in minutes instead of days. Gain an in-depth understanding of how GPUs accelerate industry-standard algorithms used in BWA-Mem, GATK4 and deep learning technologies used in variant calling such as DeepVariant.

Do you wish there were an easy way to optimize protein expression? This webinar will introduce you to three powerful strategies that can make your research more efficient: codon optimization, ribosome binding site design, and expression vector selection. We will describe the principles underlying these strategies, review case studies showing how big an impact they can have, and walk through how easy it is to use GenScript's free computational tools and best-in-class gene synthesis and cloning services to get optimized expression constructs.

Cell therapy development programs generate encouraging pre-clinical and clinical results with the promise that these tailored therapeutics can provide a curative rather than maintenance therapy. Therapies are being developed across the spectrum from academic institutions to small and medium biotechs/biopharma as well as large pharma companies which have all invested significantly in the cell and gene therapy (CGT) field. As additional CGT therapies gain approval, specifically in solid tumors and auto-immunity, the addressable patient populations will grow requiring scaled -out/-up commercial manufacturing. Although the CGT field is experiencing significant tailwinds, challenges remain. Cell sourcing has long been considered a pain-point which is potentially compounded with the necessity to develop robust GMP manufacturing processes and appropriate analytical methods.

The Alkek Center for Metagenomics and Microbiome Research (CMMR) at Baylor College of Medicine is pursuing numerous research and development efforts in the study of how the microbiome impacts human disease and how this knowledge can be translated into novel therapeutics and diagnostics. Among these efforts is a new study involving the impact of major disasters, such as Hurricane Harvey, where associated flooding and other environmental exposures to chemicals or pathogens (e.g. mold), and their impact on human health, may be reflected in the microbiome of exposed individuals.