Fast and complete cyclic peptide metabolite detection and characterization by LC-MS

Cyclic peptides have emerged as next-generation therapeutic agents, due to their unique structure and potential biological function. However, the study of cyclic peptide drug metabolism by LC-MS is challenging because these therapeutics typically do not generate high quality and interpretable fragments; and data processing is complex and tedious due to the lack of suitable software tools. This study outlines the streamlined process for analysis of cyclic peptide metabolites utilizing high-resolution QTOF analysis and MetabolitePilot Software. The unbiased data acquisition and automated detection and structural characterization of cyclic peptides will be shown using insulin and atrial natriuretic peptide (ANP) as model compounds in the biological matrix.
Watch Now

Spotlight

OTHER ON-DEMAND WEBINARS

Supporting Development of mRNA Therapeutics by Enabling Commercial-Scale mRNA Purification

Decades since the discovery of messenger RNA, mRNA-based therapeutics catapulted to the forefront of public consciousness in the form of vaccines to combat the COVID-19 pandemic.
Watch Now

Recent Advances and the Future of Antibody Engineering

genengnews

The therapeutic antibody market has reached a fever pitch of enthusiasm, in no small part due to successes of recent drug approvals for a host of disorders such as psoriasis, multiple sclerosis, C. difficile infections, and cancer.
Watch Now

Breaking Down Barriers in Healthcare: Urgency for the Clinical Laboratory to Migrate from the Background to the Forefront of Patient Care

Abbott Diagnostics

The movement towards value-based healthcare has provided a platform for a better future for all involved in the health ecosystem. However, amongst the multitude of value initiatives, the clinical laboratory has largely been left to play a secondary role. Despite its core value principles of data, timely and efficient diagnosis, and patient centricity, the lab has been relegated to near-commodity status. This is also indicative of a broader problem: a fragmented value chain that underexploits sources in decision-making, at a time when the health world’s stated focus is on outcomes.
Watch Now

National Centers for Biomedical Imaging and Bioengineering

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) supports a large network of National Centers for Biomedical Imaging and Bioengineering (NCBIB) through the P41 grant mechanism.
Watch Now

Spotlight

resources