T cell receptors (TCRs) allow the adaptive immune system to recognize and respond to a vast array of threats, ranging from viruses to malignant cells. Single-cell sequencing has made it possible to explore an individual’s TCR repertoire and quantify changes due to an immune response. To fully unlock the great potential of these measurements we need to know which antigens each TCR binds.
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There are over 7000 rare diseases worldwide, and unfortunately, less than five percent have an FDA approved therapy. The lack of valid animal models remains one of the biggest hurdles for preclinical drug discovery for rare diseases. However, recent technology advances can enable the development of innovative rodent models to speed up the drug discovery process.
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Mass spectrometry-based proteomics has been the technique of choice for deep and quantitative analysis of proteomes. However, until recently, the characterization of these proteomes was represented by the bulk analysis of many thousands to millions of cells.
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IONpath
Single cell analysis, starting with the earliest low parameter fluorescent experiments, helped define the major cell subsets of human cellular systems as we understand them today. Now, a novel combination of single cell analysis and metal isotopes based mass spectrometry (MIBI) offers a routine examination of 30+ parameters at the nanometer scale, without the interference of spectral overlap characteristic of fluorescent reporters. With this platform, we have reached new levels of organizational understanding in human pathobiology – especially when combined with novel single-cell visualization and analysis methods.
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