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Super-resolution microscopy techniques have facilitated imaging some of the smallest cellular structures with amazing detail and have led to key discoveries in molecular and cell biology, immunology, and neurobiology. Now, there is an increasing need to bring this level of detail to rapidly-occurring cellular events.
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technologynetworks
Current liquid chromatography-mass spectrometry (LC-MS) methods used to detect monoclonal antibodies (mAbs) in biological samples are focused on targeted tryptic peptide quantitation, which requires that the mAbs undergo tryptic digestion before analysis. The use of digestion complicates the workflow and can affect the results obtained. Therefore, there is an increasing interest to simplify the workflow, by developing improved methods which can detect the intact antibody or larger antibody fragments.
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Complex macromolecules are becoming a mainstay of pharmaceutical strategy, and the ability to successfully develop these biologics into viable commercial drugs is accelerating at a significant rate.
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Decades since the discovery of messenger RNA, mRNA-based therapeutics catapulted to the forefront of public consciousness in the form of vaccines to combat the COVID-19 pandemic.
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