Exploring MALDI-TOF mass spec for mycobacteria

Monoclonal antibody-based therapeutics are well established in the pipelines of biopharmaceutical organizations and have decades of development ahead. However, not all of them have disclosed or confirmed amino acid sequences. Ultra-high-performance liquid chromatography mass spectrometry provides a powerful tool to obtain the sequence information to the residue level. Historically, the process has needed expert users and therefore was extremely low throughput and is often outsourced.

The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to assist in thyroid disease management. During this session, Dr. Aw will provide a brief introduction to thyroid disease, as well as the clinical guidelines related to thyroid function tests (TFTs). Dr. Aw will also go on to explain the advantages of using TFTs as an effective tool with which to monitor thyroid health. Further, Dr. Aw will shed light on the clinical relevance and utilization of the thyrotropin receptor antibody (TRAb) test, while considering published data and findings to outline its benefits. Join us to learn more about the important role that the laboratory plays in assessing thyroid health and disease management.

Virtual or “siteless” clinical trials allow trial coordinators and patients to conduct clinical study visits via online video calls and collect data via handheld or wearable devices. In addition, virtual trials increase the size and diversity of the patient pool, accelerate recruiting, and generate more informative, clinically-relevant data that is accepted by regulatory agencies. However, moving from traditional to virtual trials presents challenges as clinical trial sponsors learn how to design, execute, and complete effective virtual trials. To assure success, trial sponsors need to better understand the digital tools and platforms used in virtual trials, how to manage the data collection they enable, and the pitfalls to avoid. In this webinar, Bernard Munos, a pioneering pharmaceutical industry innovator, and Transparency Life Sciences co-founder Dr. Tomasz Sablinski will provide an overview of the strategies leaders are finding helpful in adopting and adapting to virtual trials.

Cryo-electron tomography can visualize macromolecular structures in situ, inside the cell. Vitreous frozen cells are first thinned with a focused ion beam and then imaged in three dimensions using a transmission electron microscope. This transformative method has the power to revolutionize our understanding of cell biology, revealing native cellular architecture with molecular clarity.