Development of a Microsatellite Instability Assay Utilizing Novel Long Repeats

When assessing a potential biological therapeutic candidate, several histopathological technologies are typically employed. This ensures the target expression is validated in both normal and diseased tissues before proceeding with pre-clinical studies. Protein B is a transmembrane glycoprotein that is overexpressed in numerous cancers, including triple-negative breast cancer and is often correlated with the metastatic phenotype. In this GEN webinar, we will discuss the process involved in a typical molecular pathology laboratory. Control cell lines and the RNAScope® Assay were utilized to validate the immunohistochemistry protocol.

Upstream process development labs have historically depended on a core lab to get a picture of changes in critical media nutrients inside a bioreactor. While this became the norm, with results being delivered in weeks rather than days, the data was at least useful enough to inform future endeavors. However, recent breakthroughs in technology have changed that, as it is now possible to obtain a rapid at-line analysis of your cell media to make decisions on the fly. This webinar will introduce a powerful new platform and walk-through ways to boost your bioprocessing workflow by simply checking in more frequently. The content directly relates to anyone who is doing media quality control, media selection, or in-process media optimization and wants to accelerate their work.

From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in research due to their role as intercellular messengers in health and disease. While their translational applications appear unlimited, the study of exosomes is challenged by their small size and heterogenous nature. In this webinar you will learn more about the common methods for exosome research and the proficient tools that Miltenyi Biotec offers to isolate and analyze exosomes. Join to connect with us and hear more.

Acoustic liquid handlers have been available for more than a decade. They enable nanoliters of liquid to be accurately transferred from one well to another, without any risk of contamination or loss. The liquid handlers adapt to different fluid types and enable direct dilution of a liquid rather than serial dilution, which is prone to errors and cross-contamination. Over the past 15 years, acoustic liquid handlers have helped reduce experiment time, improved efficiency, and provided cleaner results in fields such as drug discovery and synthetic biology. However, there is room for improvement. The acoustic instrumentation can be noisy, and some machines require tricky maintenance. With its next generation of Echo® Liquid Handlers, Labcyte is addressing these concerns, as well as introducing newly developed acoustic sample tubes as an alternative to the standard well plates.