labroots
In this webinar, Marie Piketty recalls that in recent years, several cases of interference caused by Biotin have been reported, concerning doses of thyroid hormones, but also other hormones, and other dosages. Biotin also called Vitamin B7, is a cofactor of several reactions to the carboxylase. Biotin present in multivitamin cocktails, does not present a risk of interference, but the use of Biotin at supraphysiological doses as a product of "beauty" (for hair, nails and skin), or at high doses as treatment in patients with multiple sclerosis can cause interference.
Watch Now
Veeva
As scientific innovation has led to new trial designs, modern cloud technologies have enabled the industry to better manage how clinical trials are executed. Newer, more advanced cloud applications now offer unified data and process models, allowing organizations to manage their end-to-end clinical trial process within a single system. Rather than juggling individual point solutions, innovative organizations are using a unified clinical platform for greater efficiency, quality, and speed of execution. Join Veeva and Idorsia to learn how your organization can leverage a unified clinical operating model and drive new levels of efficiency across the entire clinical ecosystem.
Watch Now
We are all keenly aware that viruses can negatively impact our lives, but what about viruses that shape our existence and even improve some of its outcomes? In the past several decades, advances in cell and gene therapies have exploded due to innovations with adeno-associated virus (AAV). Yet, given its small genomic size, the life cycle of AAV is surprisingly complex. Understanding this life cycle will be pivotal to developing new and improved methods of AAV vector manufacture that can meet the industry’s increasing needs. Interestingly, in nature, AAV co-exists with adenovirus, with the latter providing help during the AAV life cycle. Thus, taking cues from nature, investigators have developed a novel tetracycline enhanced self-silencing adenoviral (TESSA) helper system that allows for contaminant-free AAV manufacture.
Watch Now
High-performance liquid chromatography (HPLC) is a proven tool for the analysis of critical process parameters (CPP) and critical quality attributes (CQA) of biotherapeutics. Historically, HPLC has been performed off-line – a process that can take days or weeks to complete.
Watch Now