Cell Therapy Manufacturing and Clinical Comparability: What, How, and When

Regenerative medicine has become a key focus worldwide and the number of stem cell therapy trials are rapidly increasing every year. Yet, large-scale and GMP-compliant stem cell manufacturing is still a major hurdle for clinical applications across the globe. In this webinar, we will show you how to implement GMP-compliant and scalable manufacturing of different adherent cell types, such as pluripotent stem cells and their derivatives, in the CliniMACS Prodigy® Adherent Cell Culture System.

Therapeutic discovery and development rely on numerous analytical techniques in order to best position candidate drugs for commercial success. Different analytical technologies are utilized for their respective strengths in maximizing understanding of candidate properties.

Soft tissue tumors are a broad group of neoplasms that involve the connective tissue of the body. Each year, over 13,000 people in the US are diagnosed with soft tissue sarcomas and over 5,000 people succumb to the malignancy. Because soft tissue sarcomas are very ambiguous and amorphous, many time sarcomas are classified as an uncertain type. Advances in immunohistochemistry, as well as the utility of novel markers such as TFE3, TLE1, MyoD1, and MUC4, have aided pathologists in classifying these soft tissue tumors. This discussion will cover the key facts and statistics about soft tissue tumors and what role IHC plays in these difficult diagnoses.

To gain insight into the immense complexity of biological structures such as the brain, it is imperative that investigators take an integrative approach that employs multi-omic technology and data. For instance, a complex neurological structure like the pituitary, which is considered the “master gland” of the endocrine system, regulates vital physiological functions, including growth, sexual maturation, reproduction, and lactation. A detailed characterization of pituitary cell populations and their underlying gene regulatory programs is needed to better understand cellular functions in this structurally complex tissue—just the right spot for some cutting-edge multi-omic studies.