CANCER ON A CHIP

Epidemiological studies show the beneficial effects of exercise during pregnancy in alleviating birth-related complications and improving neonatal metabolic health, whereas the underlying molecular mechanisms remain unclear. A protocol for maternal exercise (ME) of mice facilitates mechanistic exploration based on the regimen of the exercise guidelines for pregnant women. Treadmill exercise allows precise control of exercise intensity and duration compared to voluntary wheel running exercise, which leads to reduced variations among individual mouse within treatments and facilitates translation into ME in humans.

The accelerated expansion of manufacturing facilities needed for COVID-19 vaccines has driven the implementation of single-use technology (SUT) across many sites worldwide.

Cell culture is the unsung workhorse of biopharmaceutical drug development, yet it is so often the essential backbone of discovery projects. The growth of cells in laboratory settings constitutes a wide assortment of factors for their appropriate growth, with environmental conditions raking at the top of the list of importance. Reliable incubator technology is critical to yielding the high-quality results investigators are constantly seeking. Moreover, with respect to GMP, incubator technology must include algorithmic control systems and safeguards designed to protect the cell culture or cell-expressed product, particularly when associated with direct human applications such as cell-derived biologics and whole-cell therapies.

There are over 7000 rare diseases worldwide, and unfortunately, less than five percent have an FDA approved therapy. The lack of valid animal models remains one of the biggest hurdles for preclinical drug discovery for rare diseases. However, recent technology advances can enable the development of innovative rodent models to speed up the drug discovery process.