A CRISPR Approach to Genetic Medicine

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Interest in 3D cell culture has grown exponentially in recent years, partially due to 3D cultures helping to overcome the challenges of using animal models and inadequacy of 2D cultures. Challenges are still present because of the physical nature of 3D cultures, especially when using confocal microscopy for visualization as a result of limited light penetration through 3D structures. To overcome these limitations, Nano3D Biosciences and MD Anderson together have developed methods and protocols using magnetic 3D bioprinting techniques to successfully overcome such challenges. The results have helped to identify novel approaches to study biology using 3D cell culture and automated confocal imaging of spheroids.

In the first installment of the ASBMB Publications Technique Talks webinar series, our speakers delve into different mass spectrometry approaches with a focus on proteomics and disease.

Plasmid DNA products are one of the most common non-viral vectors, frequently used in both in vivo and ex vivo gene therapies. As a result, they can be utilised as drug substance (DS)/drug product (DP), intermediate or starting material.