Natural-based antibiofilm and antimicrobial peptides from microorganisms

Phys.org | January 02, 2019

New developments in antimicrobial peptides (AMPs) with antibiofilm properties are rapidly materializing. ABP works by inhibiting antibiotic-resistant bacteria in the biofilm through nucleotide signaling molecules. Antimicrobial peptides and antibiofilm peptide (ABP) are new antibiotic molecules derived from microorganisms for the treatment of infections. The authors have discussed the significance, limitations, and trials of these antimicrobial peptides from bacteria, fungi, protozoa, and yeast.
These antimicrobial peptides are small, cationic and amphipathic polypeptide sequences with a wide range for Gram-positive and Gram-negative bacteria, viruses and fungi with 6-100 amino acids in length. These sources are reviewed in detail showing the characterization of these antimicrobial peptides and their respective classes. The APD3 database showed 333 bacteriocin and peptide antibiotics from bacteria, 4 from archaea, 8 from protists, 13 from fungi are reported. Bacterial AMP are characterized according to their amino acid numbers and are so small in size with 1-5 kDa mass as compared to Class II AMPs are longer with an amino acid number is about 25-50.

Spotlight

Management of medication delivery through lyophilization - freeze-drying - is a crucial enabling process technology for many important parenteral drugs. Close to 50% of biopharmaceuticals, including enzymes, proteins and monoclonal antibodies, must be lyophilized as these therapeutic agents are insufficiently stable for ready-to-use solution dosage forms. A small but growing number of small-molecule drugs are also prepared in this manner. It is a safe bet that without lyophilization, the majority of these products would not be available.

Spotlight

Management of medication delivery through lyophilization - freeze-drying - is a crucial enabling process technology for many important parenteral drugs. Close to 50% of biopharmaceuticals, including enzymes, proteins and monoclonal antibodies, must be lyophilized as these therapeutic agents are insufficiently stable for ready-to-use solution dosage forms. A small but growing number of small-molecule drugs are also prepared in this manner. It is a safe bet that without lyophilization, the majority of these products would not be available.

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