Genetics may influence the effects of vitamin E on cancer risk

Medical Xpress | January 08, 2019

Almost half of all Americans take a vitamin supplement, and yet many large-scale, placebo-controlled clinical trials of various supplements have found little or no benefit. A new study led by investigators from Brigham and Women's Hospital suggests an intriguing reason for this: genetic variation may be influencing these effects, increasing risk in some individuals while decreasing risk for others. Investigators conducted a retrospective analysis of the Women's Health Study (WHS) and its genetic component, the Women's Genome Health Study (WGHS), as well as validated their results in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study (ATBC). Both of these trials investigated whether taking vitamin E supplements could affect the risk of cancer. They found that genetic variations in the gene COMT influenced whether vitamin E decreased or increased the risk of developing cancer during and after the study periods. Their results are published online in The Journal of the National Cancer Institute.

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MEDTECH

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Entos Pharmaceuticals, Inc., BioMarin | November 16, 2021

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