MEDICAL

Controlant now Providing Monitoring and Supply Chain Visibility for Pfizer-BioNTech COVID-19 Vaccine's Global Distribution

Controlant | December 16, 2020

Controlant, an leader in real-time supply chain monitoring and perceivability technologies for vigorously controlled ventures, for example, pharmaceuticals and life sciences and food and drink areas, today reported it is giving observing and Supply Chain Visibility administrations to Pfizer, comparable to the conveyance of Pfizer's mRNA-based Pfizer-BioNTech COVID-19 vaccine's worldwide circulation.

In addition to the visibility and monitoring arrangements that Controlant is providing to Pfizer to mRNA-based Pfizer-BioNTech COVID-19 vaccine distribution supply chain, the organization is likewise working straightforwardly with the U.S. Government and wellbeing authorities, for example, the Center for Disease Control (CDC), U.S. Division of Health and Human Services (HHS), and stakeholders in Operation Warp Speed, to give nearby observing at U.S. Government-preferred designated vaccination areas to help consistently guarantee coherence during hand-off, actionable communication, and visibility, all through the entirety of the U.S. supply chain journey of the vaccines.

Spotlight

Genetically engineered mice are invaluable tools for the in vivo study of gene function. The use of gene modification methods, both in embryonic stem (ES) cells and in the embryo, to modify the mouse genome has provided valuable insights into human disease and is a crucial platform for drug target discovery and validation.

Spotlight

Genetically engineered mice are invaluable tools for the in vivo study of gene function. The use of gene modification methods, both in embryonic stem (ES) cells and in the embryo, to modify the mouse genome has provided valuable insights into human disease and is a crucial platform for drug target discovery and validation.

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INDUSTRY OUTLOOK

Ionpath Expands Partnerships for Rapidly Deliver Novel Insights Utilizing Company's High-Definition Spatial Proteomics Platform

IONpath, Inc. | August 27, 2021

Ionpath, Inc., the leader in high-definition spatial proteomics, today announced a new program for biopharmaceutical research organizations interested in piloting spatial phenotyping analyses of tissue samples leveraging the company's Multiplexed Ion Beam Imaging (MIBI™) technology. Through this new program, customers can benefit from in-depth immune profiling and spatial analysis performed with the company's 30-marker Checkpoint Panel on its MIBIscope™ System. The MIBIscope platform provides a high-resolution view into the dynamics of proteins in their native tissue environment and architecture. The resulting actionable data allows researchers to not only explore the spatial relationships between a tumor and infiltrating immune cells but to also classify cells and perform the quantitative analysis of checkpoint expression that is critical to advancing immune system-based therapy development. "Since launching our Spatial Proteomic Services last year, we've seen tremendous interest in the program with more than 400% growth and significant repeat business from biopharma R&D teams who experience the unmatched impact that MIBI data brings to their prospective trial programs," said Dr. Sander Gubbens, CEO at Ionpath. "With this new pilot program, any biopharmaceutical company can quickly access high-definition spatial proteomic data and insights from our expert team that demonstrates the power MIBI data brings to their translational research." Customer tissue samples are stained with metal-tagged antibodies using a workflow similar to the gold standard IHC. The samples are then analyzed with the MIBIscope, where an ion beam liberates the metal tags that are then detected with a time-of-flight mass spectrometer – delivering fast acquisition with extraordinary resolution and sensitivity. The sample is not destroyed during imaging and can be stored for follow-on studies or utilized for additional analyses. "MIBI truly is a game changer, unencumbered by the deficiencies of fluorescent technologies," added Gubbens. "With our pilot program, new organizations will be able to see what they have been missing with other technologies and experience why our customers are expanding their use of MIBI – spanning from pre-clinical discovery to clinical trial sample analysis." The Spatial Proteomics Pilot Program uses Ionpath's 30-marker Checkpoint Panel which provides classification of 26 cell populations and expression information for all cell types. Ionpath's expert team of pathologists, immunologists and bioinformaticians deliver actionable insights including cell classification, quantitative analysis of checkpoint expression, spatial information, and comparative cohort analysis. About Ionpath Ionpath, Inc., is a pioneer in high-definition spatial proteomics, revolutionizing tissue imaging and analysis to accelerate medical discovery and improve human health. Ionpath's MIBI™ (multiplexed ion beam imaging) platform breaks through the limitations of traditional immunohistochemistry (IHC), enabling a deeper understanding of the tissue microenvironment with highly multiplexed, quantitative single-cell analysis. With MIBI technology and the expertise of world-class pathology and data science teams, Ionpath provides actionable insights for translational and clinical researchers at leading pharmaceutical, biotechnology, and research organizations in immuno-oncology, immunology, neuroscience, and infectious disease research.

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INDUSTRIAL IMPACT

Quantum Genomics Signs an Exclusive License and Production Agreement with Gulf Pharmaceuticals Industries Julphar

Quantum Genomics | December 06, 2021

Quantum Genomics, a biopharmaceutical company specializing in the development of first-in-class drugs directly targeting the brain to treat complex/resistant hypertension, has announced the signing of an exclusive license and production agreement with Julphar to market and produce firibastat in the Middle East, all African countries, Commonwealth of Independent States and Turkey. A pharmaceutical company based in the United Arab Emirates and leader in the MENA region, Julphar will receive exclusive rights to manufacture and market firibastat in the following geographic areas: the MENA1 region, CIS2, Turkey and all other countries on the African continent. With its state-of-the-art manufacturing facilities in the emirate of Ras Al Khaimah, making it possible to mass produce firibastat, Julphar will also be Quantum Genomics’ exclusive supplier for said regions. Quantum Genomics will receive up to $20M in upfront, development and sales milestone payments as well as royalties on future firibastat sales. Julphar has also pledged to invest $2M in Quantum Genomics through a private placement. Details of the transaction will be announced shortly. "Julphar, which was founded forty years ago, is one of the largest pharmaceutical companies in the MENA region. Its success has been built on its comprehensive portfolio including anti-infectives, dermatology and diabetes products and its presence in all key MENA markets. Its business is expanding fast, and cardiology is one of its key areas of investment. Julphar is also among the region’s largest producers and is the ideal partner to support firibastat’s future production needs. We’re already exploring how Julphar could meet some of those requirements for the United States and Europe," Jean-Philippe Milon, CEO of Quantum Genomics Commenting on the agreement, Dr. Essam Mohammed, Julphar’s CEO said: “Julphar is delighted to partner with Quantum Genomics to commercialize firibastat, a first in class molecule to treat resistant and difficult-to-treat hypertension, and to produce it in our state-of-the-art manufacturing facilities in Ras Al Khaimah. We are confident that firibastat will add strong value to the treatment of this unmet medical need and to Julphar’s portfolio.” Dr. Essam Mohammed added: “The new landmark agreement brings together a stronger focus on innovative ways to address critical diseases in the MENA region through manufacturing high-quality medications locally.” About Julphar Julphar is one of the largest pharmaceutical manufacturers in the Middle East and Africa, and for more than four decades, the company has been delivering high quality, innovative and affordable healthcare solutions to families across the globe. Established under the guidance of His Highness Sheikh Saqr Bin Mohammed Al Qasimi in 1980, Julphar employs 2,500 people and distributes pharmaceutical products to more than 50 countries across the globe. Julphar’s business is centered on three core business units – Julphar Diabetes Solutions, General Medicines and its consumer division, Julphar Life – which target major therapeutic segments including Gastrology, Pain Management, Wound Care, Antibiotics and Cardio-metabolism. Julphar has 13 internationally accredited facilities in the Middle East and Africa. In 2012, Julphar became one of the largest producers of Insulin with its UAE-based biotechnology production unit. About Quantum Genomics Quantum Genomics is a biopharmaceutical company specializing in the development of a new class of cardiovascular drugs, based on the Brain Aminopeptidase A Inhibition (BAPAI) mechanism. It is the only company in the world to pursue this innovative approach directly targeting the brain, founded upon more than twenty years of research work by Paris-Descartes University and the INSERM/CNRS laboratory led by Dr. Catherine Llorens-Cortès at the Collège de France. Quantum Genomics thus aims to develop innovative treatments for complicated or even resistant hypertension and heart failure.

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Bioclinica Announces That It Will Leverage Bioclinica's Interactive Response Technology (IRT) for Their EXIT COVID-19 Study

Bioclinica | September 10, 2020

Bioclinica, an integrated solutions provider of clinical life science and technology expertise, delivering powerful insight into clinical trial development in bringing new therapies to people worldwide, announced today that Direct Biologics, a market leading innovator and science-based manufacturer of regenerative products, will leverage Bioclinica's Interactive Response Technology (IRT) for their EXIT COVID-19 study — a multi-center FDA phase II clinical trial for the use of ExoFlo™ to treat COVID-19 acute respiratory distress syndrome (ARDS). "We are a dynamic and innovative biotechnology company that can engage synergistically with vendor partners who are willing and able to match our speed and adaptability in our efforts to deliver solutions for highly complex and pressing real world problems," said Dr. Vik Sengupta, Chief Medical Officer of Direct Biologics. "Bioclinica's ability to rapidly configure their highly robust and functional IRT made them the natural choice to meet our accelerating timeline in the fight against COVID-19. The Bioclinica team rose to the occasion, scaling with demand, and accommodating our specific randomization and supply chain requirements." Bioclinica's IRT is the industry's only system that provides advanced visibility to working study prototypes within just a few days - letting you build, implement, test, and deploy new protocols in as little as two to three weeks, with or without customization.

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