BioSpace Global Roundup

biospace | May 16, 2018

Gecko Biomedical – Paris-based Gecko is rebranding. The privately-owned life science company is changing its name to TISSIUM as part of an overall rebranding of the company. The new name more accurately reflects the company’s mission to develop novel solutions for tissue reconstruction for multiple clinical indications, the company announced. TISSIUM has robust product development and manufacturing capabilities and is able to bring new products to market independently, or in partnership with other industry players. Christophe Bancel, chief executive officer of TISSIUM, said the rebranding was undertaken as part of an opportunity to showcase the company’s platform of biomorphic programmable polymers that are designed to change the way the industry thinks about tissue reconstruction. The rebranding reflects that intent, Bancel said in a statement.
Valbiotis – France-based Valbiotis completed its Phase IIa study of Valedia in pre-diabetic subjects. The results of the study will be presented at a medical conference before July 31, the company said. The international Phase IIA study evaluated the efficacy of TOTUM-63, the active ingredient of Valedia, in reducing one or more of the three risk factors of type 2 diabetes. In addition to these prediabetes results, the study will evaluate other physiological parameters, including, for example, triglyceride regulation or intestinal microbiota composition.

Spotlight

The biopharmaceutical industry is at a pivotal time in medical discovery, which has enormous potential to further revolutionize the treatment of costly and debilitating diseases like Alzheimer’s, cancer, heart disease, and hepatitis C. Our ability to harness recent scientific advances continues to accelerate, and the potential benefits to patients are becoming clearer.

Spotlight

The biopharmaceutical industry is at a pivotal time in medical discovery, which has enormous potential to further revolutionize the treatment of costly and debilitating diseases like Alzheimer’s, cancer, heart disease, and hepatitis C. Our ability to harness recent scientific advances continues to accelerate, and the potential benefits to patients are becoming clearer.

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AI

WhiteLab Genomics and the Accelerator for Technological Research in Genomic Therapies Collaborate on AI for Gene Therapy Bioproduction

WhiteLab Genomics | June 01, 2021

As part of this collaboration, teams from the Accelerator for Technological Research in Genomic Therapies (ART-TG, Inserm US35) and WhiteLab Genomics will use the WhiteLab Genomics CatalystTM platform to generate a database specific to the bioproduction of lentiviral vectors, which will be used to identify the parameters allowing for a significant increase in vector quality as well as their production yields, and to reduce the production costs. Cell and gene therapy is a new biomedical approach that can treat a growing number of genetic and acquired diseases such as cancer. To keep up with their growth, the pharmaceutical manufacturing of these Advanced Medicinal Therapies needs to accelerate in terms of standardization and process control. Because purifying lentiviral vectors remains complex and at critical capacity, the partnership is focused on manufacturing lentiviral vectors, which are used in many gene therapies approaches, including the manufacture of CAR-T cells. The teams will utilize AI to analyze information from multiple sources to optimize existing processes and develop new ones. The approach used with the lentiviral vectors will apply to various bioproducts. This initiative is made possible due to funding from the Ile de France Region, which supports bioproduction efforts as part of its Ile-de-France Leader Bioproduction scheme, which was launched at the end of 2020. About ART-TG RT-TG is an Inserm innovation center located in Génopole d'Evry with the mission of promoting research excellence in gene and cell therapy by facilitating the transfer of therapeutic discoveries to clinical or industrial applications. ART-TG is a pre-industrial laboratory for testing technological innovation and pharmaceutical product and process development. ART-TG is now leading several innovative projects based on lentiviral vectors, or CRISPR genome editing tools for ex vivo uses, focusing on immunotherapy and hematology. ART-TG is a subsidiary of the industrial integrator MAGENTA (MAnufacturing Cell and GEN Therapy Advances) of the French Government Biomedicines Challenge. About WhiteLab Genomics WhiteLab Genomics, founded in 2019 by David Del Bourgo, Julien Cottineau, and Lucia Cinque, is a French start-up specialized in artificial intelligence solutions for biotherapies such as gene and cell therapies. Its proprietary technology enables multi-parametric analysis of complex biological data to optimize and reduce treatment development costs. WhiteLab Genomics makes this one-of-a-kind technology available to its clients through the Catalyst platform, which is available in SaaS mode. The start-up is presently based in Genopole - Evry, France's first biocluster, and Station F.

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AI

Deargen Announces New Model for Optimizing Drug Candidate Molecules With Nearly Doubled Performance Compared to Existing Models

Deargen | April 12, 2021

Deargen, a drug research and development biotech company based on artificial intelligence (AI), announced on April 9 that it presented study results on controlled molecule generator (CMG) technology at the ACM Conference on Health, Inference, and Learning (ACM CHIL) 2021. CMG technology can modify many properties of molecules at the same time. The Association for Computing Machinery (ACM), based in New York, is one of the world's most prominent academic organizations. The ACM was founded in 1947 and now has over 100,000 members worldwide. The ACM Conference on Health, Inference, and Learning 2021 was held online on April 8th as a healthcare conference. Deargen's latest CMG technology overcomes the limitations of current models for predicting molecule properties. Deargen's test results revealed that the new CMG method enhances efficiency by nearly doubling as compared to existing versions such as MolDQN and VJTNN. Deargen tried to improve aniracetam, which has the lowest binding affinity of dopamine D2-type receptor (DRD2) among 28 DRD2-targeted compounds in clinical or pre-clinical trials, in the most recent report. The study discovered that aniracetam's DRD2 binding affinity was highly enhanced while its other properties remained relatively unchanged. The technology of optimizing properties of candidate molecules in the process of developing new drugs, such as efficacy, toxicity, and structural similarity, is positioning itself as a key strategy for reducing costs and time required for drug development. Models that predict properties of previously proposed molecules, such as MolDQN, VJTNN, and VSeq2Seq, are considered to have limitations when used to produce new drugs because they either alter properties of molecules that must be retained by optimizing only one property or take very long to process data. Deargen's CMG model, on the other hand, will optimize only desired properties while minimizing changes in other properties that are meant to be retained as set by molecule design as it can consider multiple properties at the same time. Since it takes less time to examine, it can be directly applied to the development of new drugs. “Not only is our representative technology, MT-DTI, being used for discovering various new substances, including treatment prediction for COVID-19, but we are also poised to provide more advanced new drug development services by developing an ensemble of CMG models with our other platform MolEQ,” said Bonggeun Shin, Deargen's Chief Artificial Intelligence Officer. Deargen President Kilsoo Kang said, "Deargen has accomplished drug development technologies on a global level and continues to invest in advancing these technologies and extending their support range." “The most recent technological advancement will provide an important momentum in the development of AI-powered new drugs.”

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CELL AND GENE THERAPY

Taysha Gene Therapies Announces New Additions to Leadership Team to Deepen Manufacturing and Communications Capabilities

Taysha | December 30, 2020

Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-driven gene therapy organization focused in on creating and commercializing AAV-based quality treatments for the treatment of monogenic infections of the focal sensory system in both uncommon and huge patient populaces, today reported new increases to its authority group with the arrangements of Greg Gara as Senior Vice President of Manufacturing and Kimberly Lee, D.O., as Senior Vice President of Corporate Communications and Investor Relations. Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric gene therapy organization zeroed in on creating and commercializing AAV-based qgene therapies for the treatment of monogenic infections of the focal sensory system in both uncommon and huge patient populaces, today declared new increases to its authority group with the arrangements of Greg Gara as Senior Vice President of Manufacturing and Kimberly Lee, D.O., as Senior Vice President of Corporate Communications and Investor Relations.

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