Alligator Bioscience presents positive biomarker data demonstrating proof of mechanism in mitazalimab clinical Phase I study

PR Newswir | September 04, 2020

Alligator Bioscience presents positive biomarker data demonstrating proof of mechanism in mitazalimab clinical Phase I study
Alligator Bioscience (Nasdaq Stockholm: ATORX) announced today biomarker data from a recently performed clinical Phase I study of the drug candidate mitazalimab, its wholly owned CD40 antibody in development primarily for the treatment of pancreatic cancer. The data will be presented today at the scientific conference PEGS: The Essential Protein Engineering Summit being held virtually August 31- September 4, 2020. "The presented biomarker data confirm the proof of mechanism and strengthen our belief in mitazalimab as a powerful therapeutic agent. The observed induction of PD-L1-genes supports that mitazalimab has a potential to make tumors more responsive to PD-1 therapy. This is a very important factor and provides an opportunity for a clear path to the market and for adding benefit to patients," commented Per Norlén, CEO at Alligator Bioscience. The study identified a large number of upregulated genes after treatment with mitazalimab, such as PD-L1, which supports a clinical development plan for mitazalimab in combination studies with PD-1 inhibition. Furthermore, it was demonstrated that RNA sequencing can be successfully used to discover pharmacodynamic biomarkers following CD40 activation with mitazalimab.

Spotlight

Flow cytometry has been responsible for a myriad of discoveries since its introduction into mainstream research labs in the 1970s. From characterizing the cell cycle to identifying stem cells to unraveling the mysteries of AIDS, here are some of the moments that came about thanks to researchers having access to a flow cytometer.

Spotlight

Flow cytometry has been responsible for a myriad of discoveries since its introduction into mainstream research labs in the 1970s. From characterizing the cell cycle to identifying stem cells to unraveling the mysteries of AIDS, here are some of the moments that came about thanks to researchers having access to a flow cytometer.

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