The Beginners Guide to Nutrigenetics

| August 23, 2019

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A gene is a section of DNA that contains instructions for you to produce proteins, each of  which has a specific function in the body. We are all different, from the colour of our eyes to the curl of our hair, and this is all mostly due to genetics. Since the full genome sequence was published in 2003, we’ve come a long way in the understanding of the impact of our genes on how we look and how our bodies work. Before diving into nutrigenetics, you first need to understand the basics of genetics.

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Cargill Bioengineering LLC

Cargill Bioengineering LLC is a consulting company specializing in providing Biomedical and Biomechanical Consulting services. Cargill Bioengineering is led by Dr. Bob Cargill, a consultant with over 10 years of consulting experience and 5 years on the academic faculty of Georgia Tech. Cargill Bioengineering is responsive, effective, and efficient with experience spanning mutliple and diverse fields.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Cargill Bioengineering LLC

Cargill Bioengineering LLC is a consulting company specializing in providing Biomedical and Biomechanical Consulting services. Cargill Bioengineering is led by Dr. Bob Cargill, a consultant with over 10 years of consulting experience and 5 years on the academic faculty of Georgia Tech. Cargill Bioengineering is responsive, effective, and efficient with experience spanning mutliple and diverse fields.

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