Releasing the Handbrake on Exosome Applications

MICHELE WILSON | April 2, 2019

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Exosome are tiny vesicles that are derived from multivesicular endosomes. They are released from cells and have been shown to persist in the circulation for hours. As exosomes contain a variety of components (including proteins, lipids, mRNA and DNA) and are taken up by target cells, they are thought to represent a novel form of cellular communication. Given their resilience in extracellular fluid and unique source of origin, it is hoped that knowledge of exosomes could be leveraged for a whole host of diagnostic and therapeutic applications. Despite the great excitement about exosomes, the technology which is needed to advance this area is lacking. To find out more about the current unmet need, we spoke to Jim West, CEO of Clara Biotech, who tells us how his team is working to fill that gap. Michele Wilson (MW): Could you tell us about Clara Biotech and how it came about? Jim West (JW): The foundation of our platform came about in 2014, when Dr. He, our inventor, was working at the University of Kansas Medical Center and they started working on some exosome diagnostics, specifically around cancer. Seeing what they were doing, she was a little bit appalled at the state of the technology and the amount of effort that goes into isolating these exosomes. In addition, the technique lacked repeatability. They were very expertise-oriented. So even running the same person on the same sample over different time periods could result in different outcomes.

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MEDICAL

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DIAGNOSTICS

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Article | April 20, 2021

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InnoSer is an important, relatively new player on the market that facilitates the European scientific biomedical research in an innovative, efficient, professional and responsible manner.

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