Light and Sound Brain Wave Stimulation Shows Pre-clinical Potential As Alzheimer’s Therapy

Research presented at Neuroscience 2019, hosted in Chicago this week, has shown promising pre-clinical data in mice that suggests altering the electrical oscillations of neuronal networks with external light and sound stimulation might have brain-boosting effects that reduce pathology related to Alzheimer’s disease (AD). In a plenary talk, MIT Picower Institute for Learning and Memory Professor Li-Huei Tsai gave an overview of research which implicates aberrant brain rhythms as having a contributory role in the neurodegeneration that is a hallmark of AD pathology.

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Abena is a Danish, family-owned company manufacturing incontinence products, health care products, and baby diapers. Besides our own production in Denmark, Sweden, and France we also supply a wide range of sourced products such as; gloves, body wash, skin care, wound care, food service and paper.

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Medical

Making Predictions by Digitizing Bioprocessing

Article | August 16, 2022

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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MedTech

Laboratory Information Management System for Biotech Labs: Significance & Benefits

Article | July 13, 2022

If you have ever visited the testing laboratory of a large biotechnology company, you will be aware that managing the laboratory's operations single-handedly is no easy task. The greater the size of a lab, the more research and testing activities it must accommodate. A variety of diagnostic tests are prescribed for patients in order to detect various diseases. For example, it may include blood glucose testing for diabetics, lipid panel, or liver panel tests for evaluating cardiac risk and liver function, cultures for diagnosing infections, thyroid function tests, and others. Laboratory management solutions such as laboratory information management systems (LIMS) and other software play a significant role in managing various operational data at biotech laboratories. It is one of the important types of software developed to address thedata management and regulatory challenges of laboratories. The software enhances the operational efficiency of biotech labs by streamlining workflows, proper record-keeping, and eradicating the need for manually maintaining data. What Are the Benefits of Laboratory Information Management Software in Biotechnology? As the trends of digitization and technology continue to create deeper inroads into the biotechnology sector, a significant rise in the adoption of innovative medical software solutions, such as LIMS, is being witnessed for managing research data, testing reports, and post-research results globally. Here are a few reasons that are encouraging biotech facilities to adopt LIMS solutions Real-Time Data Collection and Tracking Previously, collecting and transporting samples was a tedious and time-consuming task. However, the adoption of LIMS with innovative tracking modules has made the job easier. The real-time sample tracking feature of LIMS has made it possible for personnel to collect the research data in real-time and manage and control the workflow with a few mouse clicks on the screen. Increase Revenue LIMS makes it possible to test workflows while giving users complete control over the testing process. A laboratory is able to collect data, schedule equipment maintenance or upgrades, enhance operational efficiency, and maintain a lower overhead with the help of the LIMS, thereby increasing revenue. Streamlined Workflow With its completion monitoring, LIMS speeds up laboratory workflows and keeps track of information. It assigns tasks to the specialist along with keeping a real-time track of the status and completion of each task. LIMS is integrated into the laboratory using lab information, which ultimately speeds up internal processes and streamlines the workflow. Automatic Data Exchange LIMS solutions store data in a centralized database. Automated transfer of data between departments and organizations is one of the major features of LIMS. Through its automated information exchange feature, LIMS improves internal operations, decreases the reporting time for data sharing, and assists in faster decision-making. Final Thoughts As the healthcare sector continues to ride the wave of digital transformation, biotech laboratories are emphasizing adopting newer technologies to keep up with the changes. Citing this trend, laboratory information management systems are becoming crucial for biotech and medical organizations for maintaining research data, instant reporting, and managing confidential, inventory, and financial data with centralized data storage.

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Research

Data Analytics: A Groundbreaking Technology in Biotech

Article | July 11, 2022

Biotechnology is a vast discipline of biology that employs diverse biological systems to create solutions that can significantly alter the ways in which they operate across various domains. That said, biotechnology is not a new notion. It has existed for millennia, with ancient civilizations using its earliest incarnations to cultivate crops and create alcoholic beverages. Today, the biotechnology industry has developed by leaps and bounds and has amassed a vast quantity of scientific data through study and research. Given the importance of data in the biotechnology business, it is not difficult to understand why biotech companies utilize data analytics. Modern data analytics tools have made it possible for researchers in the biotech industry to build predictive analytics models and gain knowledge about the most efficient approaches to accomplish their desired goals and objectives. Data analytics is increasingly being adopted by biotech businesses to better understand their industry and foresee any problems down the road. How is Data Analytics Revolutionizing Fields in Biotechnology? Today's business and scientific fields greatly benefit from data. Without the analysis of vast information libraries that provide new insights and enable new innovations, no industry can really advance. Being highly reliant on big data analytics, biotech is not an exception in this regard. With the tools and methods that help scientists systematize their findings and speed up their research for better and safer results, data analytics is making deeper inroads into the biotechnology industry. It is emerging as a crucial link between knowledge and information and is extensively being used for purposes other than just examining the information that is already available. The following are a few of the cutting-edge biotechnology applications of data analytics Genomics and Disease Treatment Pharmaceutical Drug Discovery Drug Recycling and Safety Agriculture and Agri-products Environmental Damage Mitigation Data Analytics Possibilities in Biotechnology With data analytics becoming an integral part of how biotech businesses operate, biotechnologists and related stakeholders need to understand its emergence and crucial role. Data analytics has opened new frontiers in the realm of biotechnology. Thanks to developments in data analytics, research and development activities that once took years may now be accomplished in a matter of months. Also, now scientists have access to biological, social, and environmental insights that can be exploited to create more effective and sustainable products. By understanding the importance of data-related tools and techniques applications, biotech companies are aiming to invest in the popularizing technology to stay updated in the fast-paced biotechnology industry.

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MedTech

Biotech in 2022

Article | July 11, 2022

The robust global channel of more than, 800 gene and cell curatives presently in trials will produce clinical readouts in 2022, revealing what lies ahead for advanced curatives. The impact will be felt in 2022, no matter how you slice it. Eventually, how well industry and non-supervisory bodies unite to produce new frameworks for advanced therapies will shape the year 2022 and further. Pacific Northwest talent will continue to contribute to the advancement of gene and cell curatives in both the short and long term, thanks to its deep pool of ground-breaking scientific developers, entrepreneurial directorial leadership, largely skilled translational scientists, and endured bio manufacturing technicians. We may see continued on-life science fund withdrawal from biotech in 2021, but this can be anticipated as a strong comeback in 2022 by biotech industry, backed by deep-pocketed life science investors who are committed to this sector. A similar investment, combined with pharma's cash-heavy coffers, can result in increased junction and acquisition activity, which will be a challenge for some but an occasion for others. Over the last five years, investment interest in Seattle and the Pacific Northwest has grown exponentially, from Vancouver, British Columbia, to Oregon. The region's explosive portfolio of new biotech companies, innovated out of academic centres, demonstrates the region's growing recognition of scientific invention. This created a belief that continued, especially because Seattle's start-ups and biotech enterprises are delivering on their pledge of clinical and patient impact. Talent and staffing will continue to be difficult to find. It's a CEO's market, but many of these funds' return, and are not rising in proportion to the exorbitant prices they're paying to enter deals. This schism has become particularly pronounced in 2021. Hence, everyone in biotech is concerned about reclamation and retention.

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Abena

Abena is a Danish, family-owned company manufacturing incontinence products, health care products, and baby diapers. Besides our own production in Denmark, Sweden, and France we also supply a wide range of sourced products such as; gloves, body wash, skin care, wound care, food service and paper.

Related News

The Deep Brain Origins of Alzheimer's Disease

Technology Networks | October 07, 2019

Long before symptoms like memory loss even emerge, the underlying pathology of Alzheimer's disease, such as an accumulation of amyloid protein plaques, is well underway in the brain. A longtime goal of the field has been to understand where it starts so that future interventions could begin there. A new study by MIT neuroscientists at The Picower Institute for Learning and Memory could help those efforts by pinpointing the regions with the earliest emergence of amyloid in the brain of a prominent mouse model of the disease. Notably, the study also shows that the degree of amyloid accumulation in one of those same regions of the human brain correlates strongly with the progression of the disease. "Alzheimer's is a neurodegenerative disease so in the end you can see a lot of neuron loss," said Wen-Chin "Brian" Huang, co-lead author of the study and a postdoc in the lab of co-senior author Li-Huei Tsai, Picower Professor of Neuroscience and director of the Picower Institute. "At that point it would be hard to cure the symptoms. It's really critical to understand what circuits and regions show neuronal dysfunction early in the disease. This will in turn facilitate the development of effective therapeutics."

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Alzheimer’s Memory Loss Could Be Treated with Calcium Channel Blocker

GEN | September 12, 2019

A little extra calcium is a good thing, to help maintain healthy bones and muscles. However, too much calcium in your neurons could be an underlying cause of memory loss for those afflicted with Alzheimer’s disease (AD). Alzheimer’s is the most common cause of dementia, but the changes in brain cell function that mediate memory loss remain poorly understood. However now, researchers at the University of Bristol have identified that calcium channel blockers may be an effective way of treating memory loss. Findings from the new study—published recently in Frontiers in Cellular Neuroscience through an article titled “Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease-Associated Tau by Manipulation of L-Type Ca2+ Channels”—found that treating a diseased brain cell with a blocker of the L-type channel reduced the number of calcium ions able to flow into the brain cell. “Memory loss in AD is highly distressing and a difficult to treat symptom. Targeting the early changes in brain cell function—before they begin to degenerate—may be effective in treating memory loss,” noted senior study investigator James Hodge, PhD, associate professor in neuroscience at the University of Bristol.

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Biogen and Eisai’s previously bleak Alzheimer’s study comes back with positive results

Questex LLC | July 06, 2018

A phase 2 Alzheimer’s trial once nearly consigned to the heap of disappointing attempts against the disease has re-emerged with new positive results, showing that an anti-amyloid beta protofibril antibody can slow clinical symptom decline, as well as reduce the accumulation of plaque in the brain. Biogen and Eisai’s BAN2401 did not present promising results last December, with 12-month data failing to clear the bar compared to placebo. The companies had hoped their adaptive trial design, employing Bayesian statistics, would provide a faster and cheaper route to phase 3 development compared to traditional protocols.

Read More

The Deep Brain Origins of Alzheimer's Disease

Technology Networks | October 07, 2019

Long before symptoms like memory loss even emerge, the underlying pathology of Alzheimer's disease, such as an accumulation of amyloid protein plaques, is well underway in the brain. A longtime goal of the field has been to understand where it starts so that future interventions could begin there. A new study by MIT neuroscientists at The Picower Institute for Learning and Memory could help those efforts by pinpointing the regions with the earliest emergence of amyloid in the brain of a prominent mouse model of the disease. Notably, the study also shows that the degree of amyloid accumulation in one of those same regions of the human brain correlates strongly with the progression of the disease. "Alzheimer's is a neurodegenerative disease so in the end you can see a lot of neuron loss," said Wen-Chin "Brian" Huang, co-lead author of the study and a postdoc in the lab of co-senior author Li-Huei Tsai, Picower Professor of Neuroscience and director of the Picower Institute. "At that point it would be hard to cure the symptoms. It's really critical to understand what circuits and regions show neuronal dysfunction early in the disease. This will in turn facilitate the development of effective therapeutics."

Read More

Alzheimer’s Memory Loss Could Be Treated with Calcium Channel Blocker

GEN | September 12, 2019

A little extra calcium is a good thing, to help maintain healthy bones and muscles. However, too much calcium in your neurons could be an underlying cause of memory loss for those afflicted with Alzheimer’s disease (AD). Alzheimer’s is the most common cause of dementia, but the changes in brain cell function that mediate memory loss remain poorly understood. However now, researchers at the University of Bristol have identified that calcium channel blockers may be an effective way of treating memory loss. Findings from the new study—published recently in Frontiers in Cellular Neuroscience through an article titled “Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease-Associated Tau by Manipulation of L-Type Ca2+ Channels”—found that treating a diseased brain cell with a blocker of the L-type channel reduced the number of calcium ions able to flow into the brain cell. “Memory loss in AD is highly distressing and a difficult to treat symptom. Targeting the early changes in brain cell function—before they begin to degenerate—may be effective in treating memory loss,” noted senior study investigator James Hodge, PhD, associate professor in neuroscience at the University of Bristol.

Read More

Biogen and Eisai’s previously bleak Alzheimer’s study comes back with positive results

Questex LLC | July 06, 2018

A phase 2 Alzheimer’s trial once nearly consigned to the heap of disappointing attempts against the disease has re-emerged with new positive results, showing that an anti-amyloid beta protofibril antibody can slow clinical symptom decline, as well as reduce the accumulation of plaque in the brain. Biogen and Eisai’s BAN2401 did not present promising results last December, with 12-month data failing to clear the bar compared to placebo. The companies had hoped their adaptive trial design, employing Bayesian statistics, would provide a faster and cheaper route to phase 3 development compared to traditional protocols.

Read More

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