eureKARE | July 07, 2021
eureKARE, a pioneering new company focused on financing and building next-generation biotechnology companies in the disruptive fields of the microbiome and synthetic biology, today announced an agreement with DNAlytics, a Belgian company applying data sciences to healthcare, to develop eureKARE's proprietary Artificial Intelligence (AI) platform to support its Biotech start-upstart-up studios, eureKARE.
Unlike conventional start-upstart-up incubation methods, which begin with new science and then attempt to find an issue to address with it, eureKARE's methodology reverses this. eureKARE is committed to first finding an unmet need and then enlisting the best scientists and experts to provide an innovative solution to launch exciting new ventures.
This process will be aided by eureKARE's one-of-a-kind AI platform, which will assist the business in identifying top academic researchers, locating new ideas and approaches in development, and scaling existing portfolio companies.
eureKARE is a ground-breaking new company focusing on financing and establishing next-generation biotechnology start-ups in the microbiome and synthetic biology cutting-edge areas. eureKARE employs a two-step investing strategy to create long-term value. Through its biotech start-upstart-up studios eureKABIOME (Microbiome) and eureKASYNBIO, the company promotes translational research by developing and financing new companies based on high-value European science (Synthetic biology). In addition, the company aims to engage in more mature biotech companies. It will systematically propose to provide some liquidity to early investors, thus fulfilling a crucial demand in the European biotech sector. EureKARE has a fast-expanding portfolio of companies with the potential to disrupt the life sciences sector, led by its prominent founder, Alexandre Mouradian, and a pan-European team.
DNAlytics is based in Louvain-la-Neuve, Belgium, specializing in data science for the healthcare sector, including data management, bioinformatics, biostatistics, Machine Learning, and other Artificial Intelligence methods. DNAlytics products are utilized in clinical research, the creation of biotech drugs and medical devices, public health studies, and the monitoring and optimization of bio-manufacturing processes. In addition, DNAlytics assists a wide range of clients and partners in extracting scientifically sound observations and practical conclusions from complex data sets.
GEN | November 15, 2019
Youth may be wasted on the young, but not elderliness—not when the elderliness manifests in the gut as a mature microbiome. In experiments led by scientists in Singapore, gut microbes from old mice (24 months old) were transplanted into young, germ-free mice (6 weeks old). After eight weeks, the young mice had increased intestinal growth and production of neurons in the brain, known as neurogenesis. The research team, which was based at Nanyang Technological University (NTU), showed that the increased neurogenesis was due to an enrichment of gut microbes that produce a specific short chain fatty acid, called butyrate. The scientists suggest that butyrate helps the old mice counter some of aging’s debilitating effects. In addition, the scientists speculate that butyrate-enriched foods could help slow aging, benefiting the young—and possibly the old and butyrate-deprived, too.
GEN | October 16, 2019
Scientists headed by a team at the University of Chicago have shown how genetic differences in the immune system can impact on the types of bacterial communities that colonize the gastrointestinal system. Their studies, in germ-free mice colonized with microbiomes from conventionally reared animals, found that while the makeup of the donor microbiome was the key factor in determining the recipient microbiome, genetic differences in the immune systems of the recipients also played a role. “When the input is standardized, you can compare mice of different genetic strains and see what these genetics do to the microbiome in recipient mice,” said Alexander Chervonsky, MD, PhD, who is a senior author of the team’s study, which is published in Cell Reports. “This approach allowed us to tell whether there was a genetic influence, and indeed there is.” Chervonsky and colleagues report their findings in a paper titled, “Polymorphic Immune Mechanisms Regulate Commensal Repertoire.” The bacteria that naturally live in and on us provide essential functions that are required for our very survival, the authors wrote. The composition of microbial communities varies between individuals and is influenced by a range of factors, including “… the mode of transmission during birth, breastfeeding, alimentary infections, and diet.” Previous studies have suggested that host genetics can also impact on microbial communities—identical twins tend to have more similar microbiomes than do non-identical twins—but, as the team continued, “ … two important questions remain unanswered: to what extent and which host’s polymorphic mechanisms are involved in shaping the repertoire of the commensals.”