Genomic approach to studying widespread malaria

| February 11, 2019

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Scientists at the Institute of Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM) have developed a novel way with genome sequences to study and better understand transmission, treat and ultimately eradicate Plasmodium vivax, the most widespread form of malaria. P. vivax is a single-celled transmitted by mosquitoes. It is the most widespread human malaria parasite, responsible for more than 8.5 million clinical malaria cases worldwide and threatening more than two billion people in 90 countries. 

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Australian Biobest Biotechnology Service

Australian Biobest Biotechnology Service (Biobest) is formed with a group of biotech specialists with expertise on lab bench-top biotechnology transfer to market places, biological product (especially on humanised monoclonal antibody and biosimilar) manufacturing experiences, biopharmaceutical and biological reagent marketing, licencing and registration, biomedical instrument (Biacore, Cytometer) services, scientific conference and training services, biotechnological project management and documentation and website design and biotech documentation translation.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Australian Biobest Biotechnology Service

Australian Biobest Biotechnology Service (Biobest) is formed with a group of biotech specialists with expertise on lab bench-top biotechnology transfer to market places, biological product (especially on humanised monoclonal antibody and biosimilar) manufacturing experiences, biopharmaceutical and biological reagent marketing, licencing and registration, biomedical instrument (Biacore, Cytometer) services, scientific conference and training services, biotechnological project management and documentation and website design and biotech documentation translation.

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