DNA Microscopy Changes the Way Scientists Analyze DNA

GAIUS J. AUGUSTUS | July 23, 2019

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Scientific experiments rely on many different types of data in order to form and test questions about biology. Some of those experiments provide indirect evidence about what is occurring, however, microscopes have long been used to see things we cannot view with the naked eye. The first microscopes used light and glass to magnify what was living in the water. For centuries, this let scientists “see it and believe it.”

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Parkway Pantai Limited

Parkway Pantai Limited (PPL), one of Asia’s largest integrated private healthcare providers operating in Singapore, Malaysia, India, China, Brunei and United Arab Emirates. We employ more than 19,000 staff and operate more than 6000 licensed beds across 28 hospitals in 6 countries worldwide, offering the full spectrum of integrated healthcare services from clinics to hospitals to quaternary care and a wide range of ancillary services including medical education. For over 40 years, our Mount Elizabeth, Gleneagles, Pantai and Parkway brands have established themselves as the region’s best-known brands in private healthcare, synonymous with best-in-class patient experience and outcomes. Parkway Pantai is a premier healthcare player in its home markets of Singapore, Malaysia and India and key growth markets of China and Hong Kong. It is part of IHH Healthcare, one the world’s largest healthcare groups by market capitalisation.

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MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

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Spotlight

Parkway Pantai Limited

Parkway Pantai Limited (PPL), one of Asia’s largest integrated private healthcare providers operating in Singapore, Malaysia, India, China, Brunei and United Arab Emirates. We employ more than 19,000 staff and operate more than 6000 licensed beds across 28 hospitals in 6 countries worldwide, offering the full spectrum of integrated healthcare services from clinics to hospitals to quaternary care and a wide range of ancillary services including medical education. For over 40 years, our Mount Elizabeth, Gleneagles, Pantai and Parkway brands have established themselves as the region’s best-known brands in private healthcare, synonymous with best-in-class patient experience and outcomes. Parkway Pantai is a premier healthcare player in its home markets of Singapore, Malaysia and India and key growth markets of China and Hong Kong. It is part of IHH Healthcare, one the world’s largest healthcare groups by market capitalisation.

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