Biogen cans plan to test aducanumab in Alzheimer's prevention

NICK PAUL TAYLOR | April 24, 2019

article image
Biogen has decided against (PDF) starting a phase 3 trial of aducanumab in the prevention of Alzheimer’s disease. The study was the one option for further development of aducanumab that Biogen left open when it revealed the failure of its main pivotal program last month. Upon learning that aducanumab had failed in patients with mild Alzheimer’s, Biogen and its partner Eisai shut down two phase 3 trials and two earlier-phase trials. However, the partners opted against making a quick decision about a planned study to assess whether aducanumab can delay or prevent the clinical onset of Alzheimer’s.

Spotlight

Richcore Lifesciences

Richcore Lifesciences Pvt. Ltd. is an innovation led biotechnology company developing novel enzymatic solutions for Industrial Biotechnology and Animal Origin Free recombinant proteins and enzymes for Biopharma. Richcore is venture and PE investment backed, and has multiple patent filings, and a high capacity GMP certified manufacturing plant. Its solutions are used in the global food, water, energy, and biopharma industries. At the root of its innovation is the vision and commitment to create cleaner, greener and sustainable solutions to tackle the current industrial problems. Richcore's corporate goals are aligned with the goals of the society at large to achieve meaningful economic development. Richcore intrinsically believes that doing well happens by doing good!

OTHER ARTICLES

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

Read More

Learning How FoxA2 Helps Turn Stem Cells into Organs

Article | March 18, 2020

Scientists at the Perelman School of Medicine at the University of Pennsylvania discovered early on in each cell, FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation. The discovery, “Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones,” published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs, according to the researchers. “Gene network transitions in embryos and other fate-changing contexts involve combinations of transcription factors. A subset of fate-changing transcription factors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can open the local chromatin. However, a gap has remained in understanding how molecular interactions with the nucleosome contribute to the chromatin-opening phenomenon,” write the investigators.

Read More

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

Read More

5 Biotech Stocks Winning the Coronavirus Race

Article | April 13, 2020

There are quite a few companies that have found ways to grow their business during the ongoing COVID-19 pandemic. This is especially true for a number of biotechs now working on developing a potential treatment for, or vaccine against, the virus; shares of such companies have largely surged over the past couple of months. Although many of these treatments and vaccines are still have quite a way to go before they're widely available, it's still worth taking some time to look through what's going on in the COVID-19 space right now. Here are five biotech stocks that are leading the way when it comes to addressing COVID-19. Regeneron Pharmaceuticals (NASDAQ:REGN) wasn't among the initial wave of companies to announce a potential COVID-19 drug. However, investor excitement quickly sent shares surging when the company announced that its rheumatoid arthritis drug, Kevzara, could help treat COVID-19 patients.

Read More

Spotlight

Richcore Lifesciences

Richcore Lifesciences Pvt. Ltd. is an innovation led biotechnology company developing novel enzymatic solutions for Industrial Biotechnology and Animal Origin Free recombinant proteins and enzymes for Biopharma. Richcore is venture and PE investment backed, and has multiple patent filings, and a high capacity GMP certified manufacturing plant. Its solutions are used in the global food, water, energy, and biopharma industries. At the root of its innovation is the vision and commitment to create cleaner, greener and sustainable solutions to tackle the current industrial problems. Richcore's corporate goals are aligned with the goals of the society at large to achieve meaningful economic development. Richcore intrinsically believes that doing well happens by doing good!

Events