ADC Trigger Selective Cancer Cell Death

| June 17, 2019

article image
Chemotherapy has been used to treat cancer for almost 80 years now[1] and its side effects are well known and documented. One of the main limitations associated with standard chemotherapy is the unspecific killing of healthy cells (e.g. rapidly dividing cells in the bone marrow) which is associated with high-dose requirement and low therapeutic indices. In order to significantly reduce systemic side effects, it is fundamental to develop a new generation of anticancer drugs, specifically targeting cancer cells and therefore better tolerated by patients. One approach relies on the use of monoclonal antibodies, the so-called “magic bullets” envisioned by Paul Ehrlich more than 100 years ago[2]. Monoclonal antibodies (mAbs) belong to the broad class of biological drugs, or biologics (i.e. products derived from living organisms). MAbs have fueled research in many scientific fields with four dedicated Nobel prize winners in 2018 (https://www.nobelprize.org/nobel-prizes-2018/) and can be considered today a strong clinical reality with over 80 pharmaceuticals already on the market in indications not limited to oncology[3].

Spotlight

4 Life Research

4 Life Research is a Biotechnology company located in 9850 S 300 W, Sandy, Utah, United States.At 4Life, we believe in working together to help people enjoy healthy and rewarding lives. We want you to feel good about being involved with a company where you can experience personal success and help others succeed at the same time.

OTHER ARTICLES
MEDICAL

Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

Read More
DIAGNOSTICS

Making Predictions by Digitizing Bioprocessing

Article | April 20, 2021

With advances in data analytics and machine learning, the move from descriptive and diagnostic analytics to predictive and prescriptive analytics and controls—allowing us to better forecast and understand what will happen and thus optimize process outcomes—is not only feasible but inevitable, according to Bonnie Shum, principal engineer, pharma technical innovation, technology & manufacturing sciences and technology at Genentech. “Well-trained artificial intelligence systems can help drive better decision making and how data is analyzed from drug discovery to process development and to manufacturing processes,” she says. Those advances, though, only really matter when they improve the lives of patients. That’s exactly what Shum expects. “The convergence of digital transformation and operational/processing changes will be critical for the facilities of the future and meeting the needs of our patients,” she continues. “Digital solutions may one day provide fully automated bioprocessing, eliminating manual intervention and enabling us to anticipate potential process deviations to prevent process failures, leading to real-time release and thus faster access for patients.” To turn Bioprocessing 4.0 into a production line for precision healthcare, real-time release and quickly manufacturing personalized medicines will be critical. Adding digitization and advanced analytics wherever possible will drive those improvements. In fact, many of these improvements, especially moving from descriptive to predictive bioprocessing, depend on more digitization.

Read More

Spotlight

4 Life Research

4 Life Research is a Biotechnology company located in 9850 S 300 W, Sandy, Utah, United States.At 4Life, we believe in working together to help people enjoy healthy and rewarding lives. We want you to feel good about being involved with a company where you can experience personal success and help others succeed at the same time.

Events