Accelerating R&D in Industrial Biotechnology

| June 25, 2015

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The development of industrial biotechnology is a key element of the European Commission’s strategy to reinforce the bioeconomy. This is because industrial biotechnology employs biobased catalysts, such as enzymes and microorganisms, which are exquisitely adapted for the conversion of biomolecules into products in reactions operating in aqueous, moderate conditions.

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Molecule 2 Medicine

Molecule 2 Medicine Limited (M2M) is a private, UK based, biotechnology and pharmaceutical consulting company assisting global clients with the discovery, development and commercialisation of new human therapeutics. M2M provides clients with the technical skills required to run efficient drug discovery and drug development programs, along with the financial and commercial acumen and “back office” support to help their businesses succeed. M2M ensures that the growth of each client’s science is matched by their corporate development by providing guidance in such areas as venture capital/private equity capital raisings and interactions and negotiations with Pharma partners. M2M assist in creating new biotech businesses, providing operational assistance from the formation stage and guiding the evolution of companies on the right trajectory as they strive to develop new human therapeutics.

OTHER ARTICLES

5 Biotech Stocks Winning the Coronavirus Race

Article | April 13, 2020

There are quite a few companies that have found ways to grow their business during the ongoing COVID-19 pandemic. This is especially true for a number of biotechs now working on developing a potential treatment for, or vaccine against, the virus; shares of such companies have largely surged over the past couple of months. Although many of these treatments and vaccines are still have quite a way to go before they're widely available, it's still worth taking some time to look through what's going on in the COVID-19 space right now. Here are five biotech stocks that are leading the way when it comes to addressing COVID-19. Regeneron Pharmaceuticals (NASDAQ:REGN) wasn't among the initial wave of companies to announce a potential COVID-19 drug. However, investor excitement quickly sent shares surging when the company announced that its rheumatoid arthritis drug, Kevzara, could help treat COVID-19 patients.

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Pfizer, BioNTech Plan Clinical Trial for COVID-19 mRNA Vaccine Candidate

Article | April 9, 2020

Pfizer and BioNTech plan to begin human clinical trials on their lead COVID-19 therapeutic candidate, an mRNA vaccine, by the end of this month, the companies said today, through a collaboration that could generate up to $748 million for the German biotech. The companies announced plans last month to partner on BNT162, the first treatment to emerge from BioNTech’s accelerated COVID-19-focused development program, “Project Lightspeed.” BioNTech and Pfizer established collaboration intended to draw upon BioNTech’s proprietary mRNA vaccine platforms, and Pfizer’s expertise in vaccine research and development, regulatory capabilities, and global manufacturing and distribution network.

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Closing bacterial genomes from the human gut microbiome using long-read sequencing

Article | February 12, 2020

In our lab, we focus on the impact of the gut microbiome on human health and disease. To evaluate this relationship, it’s important to understand the particular functions that different bacteria have. As bacteria are able to exchange, duplicate, and rearrange their genes in ways that directly affect their phenotypes, complete bacterial genomes assembled directly from human samples are essential to understand the strain variation and potential functions of the bacteria we host. Advances in the microbiome space have allowed for the de novo assembly of microbial genomes directly from metagenomes via short-read sequencing, assembly of reads into contigs, and binning of contigs into putative genome drafts. This is advantageous because it allows us to discover microbes without culturing them, directly from human samples and without reference databases. In the past year, there have been a number of tour de force efforts to broadly characterize the human gut microbiota through the creation of such metagenome-assembled genomes (MAGs)[1–4]. These works have produced hundreds of thousands of microbial genomes that vastly increase our understanding of the human gut. However, challenges in the assembly of short reads has limited our ability to correctly assemble repeated genomic elements and place them into genomic context. Thus, existing MAGs are often fragmented and do not include mobile genetic elements, 16S rRNA sequences, and other elements that are repeated or have high identity within and across bacterial genomes.

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Better Purification and Recovery in Bioprocessing

Article | August 2, 2021

In the downstream portion of any bioprocess, one must pick through the dross before one can seize the gold the biotherapeutic that the bioprocess was always meant to generate. Unfortunately, the dross is both voluminous and various. And the biotherapeutic gold, unlike real gold, is corruptible. That is, it can suffer structural damage and activity loss. When discarding the dross and collecting the gold, bioprocessors must be efficient and gentle. They must, to the extent possible, eliminate contaminants and organic debris while ensuring that biotherapeutics avoid aggregation-inducing stresses and retain their integrity during purification and recovery. Anything less compromises purity and reduces yield. To purify and recover biotherapeutics efficiently and gently, bioprocessors must avail themselves of the most appropriate tools and techniques. Here, we talk with several experts about which tools and techniques can help bioprocessors overcome persistent challenges. Some of these experts also touch on new approaches that can help bioprocessors address emerging challenges.

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Spotlight

Molecule 2 Medicine

Molecule 2 Medicine Limited (M2M) is a private, UK based, biotechnology and pharmaceutical consulting company assisting global clients with the discovery, development and commercialisation of new human therapeutics. M2M provides clients with the technical skills required to run efficient drug discovery and drug development programs, along with the financial and commercial acumen and “back office” support to help their businesses succeed. M2M ensures that the growth of each client’s science is matched by their corporate development by providing guidance in such areas as venture capital/private equity capital raisings and interactions and negotiations with Pharma partners. M2M assist in creating new biotech businesses, providing operational assistance from the formation stage and guiding the evolution of companies on the right trajectory as they strive to develop new human therapeutics.

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