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ON CANCER-ASSOCIATED CACHEXIA

Malignant tumors have the ability to induce a chronic and systemic inflammatory environment that gives rise to cachexia. Metastatic disease can in fact be potently active at inducing cachexia, with onset occurring in the presence of remarkably little overall tumor burden. The efficient induction of cachexia can be explained by the fact that during metastasis, hematogenous tumor cells have the opportunity to closely interact with—and activate—leukocytes. Systemic distribution of these activated inflammatory leukocytes are a source of chronic inflammation. Specifically, these inflammatory nuclei relay “danger” signals to the central nervous system (CNS) by way of the hypothalamus.

Spotlight

OXiGENE, Inc.

OXiGENE is a biopharmaceutical company seeking to realize the full potential of vascular targeted therapy (VTT) in orphan oncology indications. VTTs include vascular disrupting agents (VDAs) such as the investigational drugs that OXiGENE is developing, and anti-angiogenic agents (AAs), a number of which are FDA approved and widely used in cancer treatment. These 2 approaches (VDAs and AAs) have distinct yet complementary mechanisms of action.

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