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THE POTENTIAL OF ENGINEERED HUMAN LIVER CO-CULTURES IN PHENOTYPIC DRUG DISCOVERY FOR LIVER DISEASES

The diverse functions of the liver (i.e. albumin synthesis, glucose and fatty acid metabolism, drug metabolism) can be severely compromised by several diseases. In particular, drug-induced liver injury is a leading cause of drug attrition; hepatitis B virus chronically infects the livers of ~400 million people worldwide; hepatitis C virus chronically infects the livers of ~170 million people; and, the Plasmodium protozoan underlying malaria matures within the liver during its infection of >250 million individuals globally.