The potential of engineered human liver co-cultures in phenotypic drug discovery for liver diseases

Complex macromolecules are becoming a mainstay of pharmaceutical strategy, and the ability to successfully develop these biologics into viable commercial drugs is accelerating at a significant rate.

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Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions within a single fixed tissue sample. It is common for researchers to ask these questions before a multiplexing study begins: "How do I know what biomarkers are relevant in the tissue? Also, how do I pivot towards additional biomarkers as my research questions evolve?" Smart study design can help answer existing questions and enable continued exploration of new connections that weren’t immediately obvious at the beginning of the study. Multiplexed IF imaging can replace historical immunohistochemical staining, allowing researchers to explore more in-depth questions on the same piece of tissue.