Plants with Superpowers (GMO) Webinar

PSCs represent an important tool in a wide range of applications, including basic research, disease modeling, drug discovery, and regenerative medicine. As stem cell cultures are very sensitive and respond to the smallest influence, stable culture conditions are crucial to maintain reliability and reproducibility of experimental data. In this educational webinar we will look at the different cultivation parameters, which can affect the viability and proliferation of PSCs during expansion. Join us to learn more about how to assess the quality of your stem cells and to preserve their pluripotency.

Do you wish there were an easy way to optimize protein expression? This webinar will introduce you to three powerful strategies that can make your research more efficient: codon optimization, ribosome binding site design, and expression vector selection. We will describe the principles underlying these strategies, review case studies showing how big an impact they can have, and walk through how easy it is to use GenScript's free computational tools and best-in-class gene synthesis and cloning services to get optimized expression constructs.

MicroRNA(miRNA) are short non-coding single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. They are known to play a critical role in multiple biological processes including proliferation, differentiation, apoptosis, and hematopoiesis. Dysregulation of miRNA expression, therefore, is associated with a number of pathological conditions such as inflammation, cardiovascular diseases, neurological disorders and several types of cancers. miRNAs are also found to be extremely stable in body fluids such as serum, plasma, urine, breast milk, and saliva. Extracellular miRNAs are either packed into exosomes or loaded into high-density lipoproteins or bound by AGO2 proteins outside on vesicles. These modes of action protect miRNAs from degradation and improve their stability. Because of their stability in body fluids, miRNAs are gaining importance as biomarkers in liquid biopsies.

To gain insight into the immense complexity of biological structures such as the brain, it is imperative that investigators take an integrative approach that employs multi-omic technology and data. For instance, a complex neurological structure like the pituitary, which is considered the “master gland” of the endocrine system, regulates vital physiological functions, including growth, sexual maturation, reproduction, and lactation. A detailed characterization of pituitary cell populations and their underlying gene regulatory programs is needed to better understand cellular functions in this structurally complex tissue—just the right spot for some cutting-edge multi-omic studies.