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MIND THE YAP! SINGLE-CELL TRANSCRIPTOMES REVEAL DRIVERS OF INTESTINAL REGENERATION

SHARESHARESHARE
Controlling organ growth size is an evolutionarily conserved process regulated by molecules within the Hippo pathway—a unique signaling module that regulates cell-specific transcription in response to a wide range of intra- and extracellular cues. In addition to its conventional role in restricting tissue size during development, Hippo signaling has been widely identified as an important regulator of cellular migration and cell survival, as well as playing a role in the development of various human cancers.