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ADVANCING PRECISION IMMUNOTHERAPY THROUGH NEXT-GENERATION SEQUENCING OF T CELL RECEPTORS: PART I

SHARESHARESHARE
This webinar will review recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires towards predictive and mechanistic biomarker discovery for cancer immunotherapy. Dr. Looney will focus on immunotherapy biomarker applications of a long-amplicon TCRB sequencing assay which provides coverage of the CDR1, 2 and 3 regions of the rearranged TCRB chain. He will highlight recent data from individuals receiving checkpoint blockade immunotherapy for cancer which suggest that long-amplicon TCRB repertoire sequencing of pre-treatment peripheral blood may be used to identify predictive biomarkers for immune-mediated adverse events and objective clinical response.