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Stem Cells Might be Heading Soon to Dental Offices for Tooth Repair

August 12, 2019 / GEN

An international team of scientists, including researchers from the Biotechnology Center of the TU Dresden BIOTEC, says it has found a new mechanism that could offer a potential solution to tooth repair. They discovered a new population of mesenchymal stromal cells in a continuously growing mouse incisor model. They have shown that these cells contribute to the formation of dentin, the hard tissue that covers the main body of a tooth. Importantly, the work showed that when these stem cells are activated, they send signals back to the mother cells of the tissue to control the number of cells produced, through a molecular gene called Dlk1. This study (“Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation”), which was published in Nature Communications, reportedly is the first to show that Dlk1 is vital for this process to work. In the same study, the researchers also demonstrated that Dlk1 can enhance stem cell activation and tissue regeneration ...