. home.aspx

NEWS

home.aspx
   


Stabilizing ends of chromosomes could treat age-related disease

March 28, 2019 / Baylor College of Medicine

A study led by researchers at Baylor College of Medicine has uncovered a new strategy that can potentially treat age-related disease and decline. The study, published in the journal Cell Metabolism, demonstrates that shortening of telomeres the ends of the chromosomes—impairs a class of enzymes called sirtuins, which play an important role in maintaining cell fitness by affecting many metabolic processes and repairing damaged chromosomes. The researchers showed that restoring the activity of sirtuins with a small compound stabilized telomeres and reduced DNA damage, which in turn improved liver disease in a mouse model. These studies suggest that maintaining telomere length might help sustain the regenerative capacity of cells and tissues and improve disease outcome. "Our genetic material is tightly packed into thread-like structures called chromosomes and at the ends of the chromosomes are particular pieces of DNA called telomeres. Telomeres work like the plastic tips at th...